Stem Cell Therapy

What is Stem Cell Therapy?

Stem cell therapy is a non-invasive treatment that aims to replace damaged cells within the body. Mesenchymal stem cell therapy can be deployed systemically via IV or injected locally to target specific sites, depending on patient needs.

Erectile Dysfunction (Impotence) Treatment with Stem Cells

Stem cell therapy is applied as the most successful treatment method in the treatment of erectile dysfunction in the world in terms of both ease of treatment and definite successful results in patients with impotence (erectile dysfunction).

• Stem cell therapy in impotence completely eliminates the erection problem as they touch and transform the cells that provide erection in the penis.
• The treatment can be applied to patients of all ages who have erectile dysfunction.
• Stem cells taken from the patient are multiplied in stem cell laboratories and given to the patient by intravenous line and/or injection into the penis.
• Stem cell therapy provides at least %90-95 improvement after the first application in patients with Erectile Dysfunction (impotence / erection) problem, while it provides definite results in continued applications.

Treatment Phase

Stem cells are obtained from adipose tissue and bone marrow. Removal of cells is done under light sedation and local anesthesia so that the patient does not feel pain. Stem cells in the fat tissue taken from the pelvis or belly are separated by filtering under sterile conditions. These taken cells are injected into the penis. Stem cells create growth and vascularization in the penis. Existing veins dilate. The number of veins increases. 

In sperm deficiency disease, the stem cells given to the person transform into sperm cells, which are few in number, and allow them to multiply. It is observed that patients who have not been able to have children for years due to lack of sperm after treatment are able to have children. The success rate in patients who are suitable for treatment is 95% and above.

This treatment using high technology is completely painless. Since your own stem cell is used, it has no side effects. At the end of the first month, a revival begins to be seen in the penis. Functionality is gained from the 3rd month.

Can stem cell therapy in impotence be applied to patients of all ages?

Stem cell therapy can be applied to patients of all ages who have erectile dysfunction.

Does stem cell therapy in impotence give results at once?

While stem cell therapy provides definite success in one go in patients suffering from impotence, the treatment can be repeated if the patient wishes, depending on age progression or performance increase demand.

What is stem cell therapy?

Stem cell therapy is a form of regenerative medicine designed to repair damaged cells within the body by reducing inflammation and modulating the immune system.  This phenomenon makes stem cell therapy a viable treatment option for a variety of medical conditions.  Stem cell therapies have been used to treat autoimmune, inflammatory, neurological, orthopedic conditions and traumatic injuries with studies conducted on use for Crohn’s disease, Multiple Sclerosis, Lupus, COPD, Parkinson’s, ALS, Stroke recovery and more.

While stem cell therapy does not necessarily provide a cure for these conditions, the premise is to allow the body to heal itself well enough to mitigate the symptoms of the conditions for long periods. In many cases, this effect can substantially increase the quality of life for patients as well as delay disease progression.

Where do stem cells come from?

Stem cells can be obtained from many different sources. These include adipose (fat tissue), umbilical cord tissue, placental tissue, umbilical cord blood, or bone marrow.

‍How are stem cells administered?

Stem cells can be administered in a variety of fashions; IV Stem Cell Therapy (Intravenous administration), Intrathecal (directly into the spinal canal), Site injections into problem areas (Knee, hips, hands, etc.)

How does stem cell therapy work?

Mesenchymal stem cells utilize their self-renewal, immunomodulatory, anti-inflammatory, signaling, and differentiation properties to influence positive change within the body.  Mesenchymal stem cells (MSCs) also have the capacity to self-renew by dividing and developing into multiple specialized cell types present in a specific tissue or organ.  Mesenchymal stem cells are adult stem cells, meaning they present no ethical concerns, MSCs are not sourced from embryonic material.

“The characteristics of presenting no major ethical concerns, having low immunogenicity, and possessing immune modulation functions make MSCs promising candidates for stem cell therapies.” – Jiang, et al. (10)

Stem cells target inflammation

The therapeutic uses of stem cells as a potential therapy for a variety of diseases has been immensely explored, the number of clinical trials conducted with Mesenchymal Stem Cells has increased exponentially over the past few years. (4)

Stem cells have a unique, intrinsic property that attracts them to inflammation in the body. Studies have shown that stem cells can regenerate damaged or diseased tissues, reduce inflammation and modulate the immune system promoting better health and quality of life. Mesenchymal stem cells do this by influencing tissue repair via paracrine effects (cell signaling in order to change the behaviour of existing cells) or direct cell-to-cell contact.

“MSCs are able to migrate and seed specifically into damaged tissue sites, where they can differentiate into functional cells to replace damaged or diseased cells” (4)

A recent study conducted by Mao F. et al. found that Mesenchymal stem cells (MSCs) facilitate tissue regeneration through mechanisms involving self-renewal and differentiation, supporting angiogenesis and tissue cell survival, and limiting inflammation.” (3)

What are stem cells?

Stem cells are the body’s raw materials — cells from which all other cells with specialized functions are created. Mesenchymal stem cells are adult stem cells that have self-renewal, immunomodulatory, anti-inflammatory, signaling, and differentiation properties.  Mesenchymal stem cells (MSCs), self renewal capacity is characterized by their ability to divide and develop into multiple specialized cell types present in a specific tissue or organ.

Mesenchymal stem cells (MSCs) can be sourced from a variety of tissue including adipose tissue (fat), bone marrow, umbilical cord tissue, blood, liver, dental pulp, and skin. 

MSCs are widely used in the treatment of various diseases due to their self-renewable, differentiation, anti-inflammatory, and immunomodulatory properties. In-vitro (performed in a laboratory setting) and in-vivo (taking place in a living organism) studies have supported the understanding mechanisms, safety, and efficacy of MSC therapy in clinical applications. (3)

According to Biehl et al., “The two defining characteristics of a stem cell are perpetual self-renewal and the ability to differentiate into a specialized adult cell type.” (1)

Mesenchymal stem cells have the ability to turn into new types of cells

A stem cell can become many different cell types in the human body. The process of stem cells maturing into new types of cells is called differentiation. This process is the most critical aspect of stem cell therapies, as the cells become the type of cells required for one’s body to heal.

‍Umbilical Cord Tissue-Derived Mesenchymal Stem Cells (UC-MSCs)

UC-MSCs can be sourced from a variety of areas including Wharton’s Jelly, cord lining, and peri-vascular region of the umbilical cord. As a commonly discarded tissue, the umbilical cord contains a rich source of mesenchymal stromal cells, which are therefore obtained non-invasively (5).

“UC-MSCs are the most primitive type of MSCs, shown by their higher expression of Oct4, Nanog, Sox2, and KLF4 markers.” (6)

Umbilical cord tissue-derived mesenchymal stem cells have the ability to differentiate into different cell types and have the greatest proliferation rate of the three mentioned types of stem cells (adipose, bone marrow, cord tissue). (7)

Similar to adipose tissue and bone marrow-derived MSCs, UC-MSCs are known to secrete growth factors, cytokines, and chemokines, improving different cell repair mechanisms. (4). These functions all assist the anti-inflammatory and immunomodulatory properties of MSCs.

Non-invasive cell product

The harvesting procedure of UC-MSCs is non-invasive as it does not require extraction from the patient.  The MSCs are taken directly from an area of an ethically donated human umbilical cord.

UC-MSCs also have a high proliferative potential than BMSCs and ASCs meaning they expand in vitro more effectively allowing for greater efficiency when obtaining higher cell numbers. (15)

Studies have found that UC-MSCs genes related to cell proliferation (EGF), PI3K-NFkB signaling pathway (TEK), and neurogenesis (RTN1, NPPB, and NRP2) were upregulated (increase in the number of receptors) in UC-MSCs compared to in BM-MSCs. (15)

Umbilical cord tissue diagram showing where stem cells originate

Pictured: Umbilical cord tissue diagram showing where stem cells originate

Does stem cell therapy in impotence give results at once?

While stem cell therapy provides definite success in one go in patients suffering from impotence, the treatment can be repeated if the patient wishes, depending on age progression or performance increase demand.

Differentiation (becoming new types of cells)

Mesenchymal stem cells are multipotent stem cells that can self-renew and differentiate into different cell types. In other words, mesenchymal stem cells can become a variety of different cell types including; adipose tissue, cartilage, muscle, tendon/ligament, bone, neurons, and hepatocytes (8)

According to a 2016 study conducted by Almalki et al. –  “The differentiation of MSCs into specific mature cell types is controlled by various cytokines, growth factors, extracellular matrix molecules, and transcription factors (TFs). (8)

Mesenchymal stem cells contribute to tissue regeneration and differentiation, including the maintenance of homeostasis and function, adaptation to altered metabolic or environmental requirements, and the repair of damaged tissue. (9)

Stem cells age as we do

Stem cell numbers and effectiveness begin to decrease as we age exponentially. For example, stem cells from a person in their twenties are not nearly as high quality as the brand new cells sourced from umbilical cord tissue.

How is stem cell therapy utilized?

Stem cell therapy may be able to treat orthopaedic, inflammatory, autoimmune and neurological conditions, with studies conducted on use for Crohn’s Disease, Multiple Sclerosis, Lupus, COPD, Parkinson’s, ALS, Stroke recovery and more.

Stem cells do not necessarily provide a cure for these conditions. The premise is allowing the body to heal itself well enough to mitigate the symptoms of the conditions for long periods. In many cases, this alone allows for a substantial increase in quality of life for patients.

Will the body reject stem cells?

Cord-tissue derived mesenchymal stem cells do not have any risk of rejection within the body. They are youthful, immune-privileged, undifferentiated cells that have no rejection in the body because they have yet to be “claimed.”

There are no blood products associated with them either, removing the need for a donor match; they are universally accepted. These cells seek out inflammation in the body and begin to heal the damaged tissue. Mesenchymal cord tissue-derived stem cells have been administered thousands of times at clinics around the world without instances of rejection (graft vs. host disease).

Why use umbilical cord tissue?

Cord tissue is rich in mesenchymal stem cells, potentially used to help heal, regenerate & treat a variety of conditions. Mesenchymal Stem Cells (MSCs) derived from umbilical cord tissue have shown the ability to avoid a negative response from a person’s immune system, allowing the cells to

Conclusion

Previously untreatable neurodegenerative diseases may now possibly become treatable with advanced stem cell therapies.  Regenerative medicine and its benefits may be the key to prolonging human life.

DISEASES TREATED BY STEM CELL APPLICATION

STEM CELL – DIABETES

Mesenchymal Stem Cell Therapy in Diabetes Type-1 and Type-2 DiseaseAs a result of the treatment of diabetes patients with stem cells; 50-70% reduction in blood sugar level and insulin dose taken from outside could be achieved. More than 50% of cases have improved with stem cell therapy. It has been reported that Mesenchymal stem cells, in particular, have an effect on the vascular damage caused by diabetes, the repairing function of tissues and organs, prolonging the life expectancy of the patient and increasing the comfort of life. One of the biggest problems faced by diabetes patients is organ or tissue failure, which manifests itself with wounds on the feet, deterioration of kidney functions, and inadequate oxygenation and nutrition in many organs due to vascular damage in the medium term. Stem cells, especially by supporting the repair and regeneration of vessels, protect tissues and organs that are highly affected by diabetes, such as kidneys. Then, by providing immune-modulation in its content, it reconstructs immune cells that have fought against insulin-producing beta cells. Recovery is rapid after stem cell transplantation. At the end of the 3rd month of the patients; Reduces the dosages of the drugs used, a more lively and healthy appearance, a 40-70% decrease in post-meal blood glucose levels compared to the previous values, improvement in HbA1C values, increased sexual performance, increased blood supply in the feet and the appearance of living tissue due to kidney functions, urea and creatinine values ​​have been reported to improve.

STEM CELL – MUSCLE

With Stem Cell therapy, the progression of muscle wasting can be slowed down, regressed or even completely stopped. The success rate of treatment is proportional to the age of the patient, the duration of the disease and the patient’s condition.   

• Muscle wasting treatment with stem cells is accepted as a new method that world scientists are working on.
• Stem cells have the ability to transform into damaged muscle cells when they touch them, so they are used in the treatment of muscle wasting.
• The number of cells to be given is determined according to the age and weight of the patient. The treatment is carried out with the patient’s own fat tissue or obtained from the stem cell bank (Mesenchymal stem cell produced from the cord blood of babies). The decision is made according to the patient’s condition. It is performed in 3 sessions with 45-day intervals or by application for 3 consecutive days.
• A success rate of 88% was achieved in areas such as general improvement in quality of life, regression of the disease and strengthening of the immune system in patients with different degrees.Muscle Wasting Disease Treatment with Stem CellsThe success rate of the treatment is directly proportional to the age of the patient, the duration of the disease and the current condition of the patient. Stem cells have the ability to transform into damaged muscle cells when they touch them, so they are used in the treatment of muscle wasting. However, since this disease is caused by a gene defect, stem cells that are not genetically defective and usually obtained from the fetus can be applied to the patient.On the other hand, if it is ensured that the stem cells obtained from the patient are not infected, the patient’s own stem cells can also be used. In this way, it can slow down the progression of the disease, completely stop it and ensure its regression. If the disease is very advanced, more than one treatment may be required. This treatment can be performed at our Clinic and Turkey Stem Cell Treatment Center in Istanbul, Turkey.

STEM CELL – EYE

New horizons in the eye: Stem cell therapyStem cell applications, which stand out in many fields of medicine, are also used in the treatment of some eye diseases. Treatments performed in eligible patients with the approval of the Stem Cell Advisory Board within the Ministry of Health give hope to the patients.Stem cells can renew themselvesSome retinal diseases can be treated with intraocular injections, which have been introduced in recent years. In the first row of this group; bleeding and edema due to diabetes, retinal vascular occlusions and wet-type macular degeneration. Pointing out that stem cell therapy has come to the fore in recent years in genetically inherited retinal diseases that occur at a young age and cause progressive vision loss, doctors point out that it is necessary to define stem cells first and continue as follows: “Simply; This progenitor cell, which is the purest and most basic form of the cell, has the ability to transform into other cells in the human body. Stem cells can spontaneously settle in a suitable growth environment, reproduce, differentiate into other types of cells and produce species that follow. In addition, it can renew itself as well as its own cell communities. they can ensure its continuity. Following an injury to a part of the body, they have the potential to repair this tissue and make it functional. Due to these potentials, it can replace damaged cells in the retina as well as repair them. Their current properties also lead to the research and use of stem cells as a treatment option in many diseases.”Mesenchymal stem cells are usedPatients who are candidates for stem cell therapy need to undergo some tests. Visual field, OCT (optical coherence tomography) and electrophysiology tests are used to evaluate whether the person is suitable for stem cell application. In ideal patients, approval is obtained by applying to the Stem Cell Advisory Board within the Ministry of Health before the application. Stating that the surgery program was performed after the approval, he explains the implementation of the treatment as follows: “In our clinic, mesenchymal stem cells originating from the umbilical cord (umbilical cord) are used as the cell type. As a method of application, suprachoroidal (outer layer of the eye) application is preferred because it is safer and does not prevent other treatments to be performed afterwards. The surgical procedure can be performed under general or local anesthesia according to the patient’s request. The surgery can be applied to one eye or to both eyes in the same session, depending on the patient’s request. After the surgery, the patient is treated with drops for a month. Check-ups take place in the first, third and sixth months after the first day after the surgical procedure.It can be used in the treatment of many eye diseases.Stem cell applications are mostly used in hereditary retinal, optic nerve and hereditary corneal diseases. Among the applied retinal diseases, retinitis pigmentosa known as night blindness or chicken black, Stargardt macular dystrophy, especially the dry type of age-related macular degeneration, namely macular degeneration, and other degenerative retinal diseases can be counted. Optic nerve diseases include optic atrophy caused by glaucoma, idiopathic, traumatic or other causes.

WHAT IS STEM CELL TREATMENT IN ORTHOPEDIC DISEASES?

Stem cells are the main cells found in all tissues in the human body. These cells, which have the potential to transform into all other existing cells, are present in the embryonic, that is, in the first developmental stage in the mother’s womb, and in the form of adult stem cells, being more intense in some parts of the body. When tissue damage occurs, these cells become active and release the growth factor needed for the repair of damaged tissue, and on the other hand, they turn into tissue-specific cells needed for healing. They serve in the healing and repair phase of the body. Today, many studies have been carried out for this purpose and it has been actively used in clinics because the results are significantly satisfactory.Adult stem cell sources are used today, since the removal of stem cells from fetuses has both legal and ethical problems. Stem cell therapy is used in orthopedics to stop the progression of cartilage damage and support its healing in patients who have a painful joint with cartilage damage in the early period, but are too early for surgical treatment or do not want to have surgery.In Which Orthopedic Diseases Is Stem Cell Therapy Used?Stem cells are used in joints such as knee, hip and shoulder that have been exposed to cartilage injury. In this application, which has important features in terms of usage area, age, gender and level of disease are very important. It is not the right approach to apply stem cell therapy in every case and to draw a miraculous picture of well-being for the patient. It is not a correct approach to present it as a treatment option in cases of loss of almost all joint cartilage capacity. For this reason, it is very important to choose the right patient, since the area of ​​​​use is not very wide.

STEM CELL TREATMENT IN ORTHOPEDIC DISORDERS

In stem cell therapy, which is generally applied in musculoskeletal diseases, cells are usually obtained from the patient’s fat structure or stem cell bank (Mesenchymal stem cell produced from the cord blood of babies). Stem cells can be reproduced by producing the tissue sample taken in cell culture or by using special centrifuge systems, stem cells can be concentrated. Cell culture processes need to be carried out under special laboratory conditions to prevent disease transmission and to prevent unwanted cells from being transplanted. The reproduced cells are then transplanted into the diseased areas, where treatment is provided. This transplantation process is done by absorbing the stem cells into tissues called matrix, which is a carrier, and the resulting preparation is placed on the damaged area by surgically opening the joint and fixed with various adhesives. It is aimed that the applied matrix transforms into cartilage cells and forms a repair tissue in the damaged area. Stem cells do not make any changes in the genetic makeup of the person and are not considered as gene therapy.

Frequently Asked Questions

What are the results of stem cell therapy?

The methods of using stem cells in cartilage diseases have been researched with numerous animal experiments, and then applications in humans have come to the fore. However, the results of treatment applications on humans show that it is still not 100% sufficient. The created cartilage structure does not resemble the original structure and its durability is debatable. However, it is seen that a better quality improvement is achieved.

Are there risks to stem cell therapy?

Stem cells have the potential to transform into any type of cell. Due to this feature, it has been reported that sometimes stem cells transform into a bone-like tissue other than cartilage. It has been reported that it sometimes causes surface swelling within the joint and requires secondary surgical trimming.There are various studies on the use of stem cells in the repair of cartilage injuries, and many studies are still ongoing. It is hopeful that there are many studies on the subject. Which of the methods described above is better is still a matter of debate, but studies on this subject continue. Although the quality and durability of the resulting cartilage tissue and ensuring its integrity with the surrounding cartilage are obtained by these methods, a long-term result is not known yet.

PARKINSON TREATMENT WITH STEM CELL

With Stem Cell therapy, the progression of Parkinson’s disease can be slowed down, regressed or even completely stopped. The success rate of treatment is proportional to the age of the patient, the duration of the disease and the patient’s condition. With the improvement to be achieved in the muscles, the quality of life of the patient increases significantly. The treatment of Parkinson’s disease with stem cells is accepted as a new method that world scientists are working on.

• Stem cells have the ability to transform into damaged brain cells when they touch them. Stem cells are therefore used in the treatment of Parkinson’s.
• The number of cells to be given is determined according to the age and weight of the patient. The treatment is carried out with 3 sessions with 45-day intervals or 3 consecutive days of application.
• The treatment protocol is completely adjusted according to the patient’s condition, a different protocol is applied for each patient.
• The size of the stem cells given is small enough to pass through the brain cells. For this reason, the success rate of treatment increases significantly in early diagnosis.In studies, very positive results have been obtained with stem cell therapy. It largely prevented the progression of the disease to more advanced stages in 74% of the patients and helped to improve the existing bad situation.

STEM CELL -AUTISM

Autism Treatment with Stem CellsWith Stem Cell Therapy, the progression of the disease to more advanced stages is largely prevented in autism patients and improvements are achieved in their current condition. After the treatment, cognitive development, increase in learning capacity, being more efficient and diligent, remembering information in a shorter time and keeping it in memory for a longer time, increase in environmental adaptation, gastrointestinal (digestive system) function development, immune system development are observed.

• Stem cells have the ability to transform into cells they touch, such as nerves, brains and muscles, so they are used in the treatment of autism. The stem cells transplanted to the patient are stem cells that do not genetically carry this disorder. For this reason, they can slow down the progression of the disease by replacing the damaged cells, stop it completely and make it regress.
• The number of stem cells to be given is determined according to the age and weight of the patient. The treatment is carried out with 3 sessions with 45-day intervals or 3 consecutive days of application.
• The treatment protocol is completely adjusted according to the patient’s condition, a different protocol is applied for each patient.
• A very high rate of positive results have been observed with stem cell therapy in patients with autism. In 85% of the patients, the progression of the disease to more advanced stages was largely prevented and the current situation was improved.

What is Autism?

Autism is a neurobiological disorder, which is considered to be caused by the different structure or functioning of the brain and nervous system, which occurs with communication and social interaction problems, limited interests and repetitive behaviors.Autism, which prevents interacting with others and causes the person to be alone with his own inner world, usually appears in the first 3 years of life and negatively affects the social communication, interaction and behavior of individuals. It is possible to minimize the effects of the disease with the rehabilitation programs and treatments to be applied.Autism Treatment with Stem CellsStem cells are natural repairers that make up all the tissues and organs in our body, have the ability to transform into the cells they touch and divide unlimitedly, and can regenerate and heal our entire body. Therefore, they can be used in the treatment of Autism.Although the success rate in the treatment of the disease is directly proportional to the age of the patient, the duration of the disease and the existing condition of the patient, 85% success has been achieved in slowing, completely stopping and regressing the progression of the disease in 90% of the cases. The results obtained from the patient are evaluated according to the positive increase within 1 year. If positive results are started, the treatment is repeated and the success rate is increased.The following successes can be achieved by combining stem cells and routine therapies;

• Cognitive development.
• Increased development of learning capacity
• Development of being more competent and diligent
• The development of remembering information in a shorter time and keeping it in memory for a longer time
• Environmental and adaptive development
• Gastrointestinal (digestive system) function development
• Immune system development

Method of Application:

The number of cells to be given; determined by the age and weight of the patient. The treatment is carried out with Mesenchymal stem cells produced from the cord blood of babies obtained from the stem cell bank. Which treatment will be applied is decided according to the patient’s condition. It can be performed in 3 sessions with 45-day intervals or by application for 3 consecutive days. The treatment protocol is completely adjusted according to the patient’s condition, a different protocol can be applied for each patient.

Frequently Asked QuestionsWhat is the Success Rate of Stem Cell Therapy?

The size of the stem cells given is small enough to pass through the brain cells. For this reason, the success rate of treatment increases significantly in early diagnosis. In studies, very positive results have been obtained with stem cell therapy. In 85% of the patients, it largely prevented the progression of the disease to more advanced stages and improved the existing bad situation. The most clear and lasting effects of the applied treatments were achieved in the initial stage of the disease (in 90% of cases), when neurological and mental symptoms appear. The results obtained from the patient are evaluated according to the positive increase within 1 year. If positive results are started, the treatment is repeated and the treatment success rate is increased. 

EMPOWERMENT (HARDING PROBLEM)

Stem cell therapy in patients is applied as the most successful treatment method in the treatment of erectile dysfunction in the world in terms of both ease of treatment and definite successful results.

• Stem cell therapy in impotence completely eliminates the erection problem as they touch and transform the cells that provide erection in the penis.
• The treatment can be applied to patients of all ages who have erectile dysfunction.
• Stem cells taken from the patient’s fat tissue are centrifuged in stem cell laboratories, multiplied and given to the patient by intravenous line and/or injection into the penis.
• Stem cell therapy provides at least 50% improvement after the first application in patients with Erectile Dysfunction (impotence / erection) problem, while it provides definite results in continued applications.What is Erectile Dysfunction (Impotence)?Erectile dysfunction (impotence) is the name given to the problem of the penis not being erect enough to enable and maintain sexual intercourse. Erection (hardening) is a process that occurs under the influence of physical, hormonal and psychological factors. Inability to achieve an erection is a functional problem. While there may be many reasons for an erection to fail, it is testosterone, known as the male hormone, that manages the process.What are the Symptoms of Erectile Dysfunction (Impotence) Disease?Experiencing erectile dysfunction once does not lead to a diagnosis of erectile dysfunction. Frequent or persistent erectile dysfunction during intercourse is a sign of erectile dysfunction.

HAIR TRANSPLANTATION WITH STEM CELL

Stem cells are precursor cells found in the body that can differentiate into various cell types. Hair follicles also contain stem cells. However, hair stem cells may be damaged or inactive in cases that result in male or female pattern baldness. By injecting stem cells from the oil into the scalp, they can repair damaged hair follicles and effectively stimulate new hair growth. A revolutionary “hair stem cell therapy” has emerged in hair loss using stem cells obtained from oil. The reason for choosing fat as a source of stem cells is that it is the tissue with the highest number of stem cells in the body. So much so that there are 1000 times more stem cells than bone marrow in adipose tissue.   For hair stem cell treatment, stem cells are separated within 1-2 hours with a special process from the fat taken from the body parts (abdomen, hips, etc.) Stem cells separated from the fat are injected into the hairy and balding skin. Hair treatment with stem cells strengthens existing hair follicles and activates dormant hair follicles to enter the growth phase. Stem cell therapy to the hair can activate the existing inactive and weak hair follicles and encourage them to grow.“Stem cell therapy can be applied as a stand-alone treatment for hair loss or in combination with hair transplantation to achieve better results.”To

Whom Is Stem Cell Hair Treatment Applied?

Stem Cell Hair Treatment is a suitable method for people who want to slow down the shedding by strengthening their hair, who want stronger hair with a healthier look, and who have weak and thin hair. With the application of stem cells to the hair, it is aimed to support the hair follicles, to slow down the hair loss and to increase the durability of the weak existing hair.Hair Stem Cell Treatment PricesHair stem cell treatment prices can be said in the healthiest way after examining the patient. Treatment modalities, combined applications can change the prices of hair stem cell therapy. You can contact us for detailed information about the price of stem cells for hair.

Hair Stem Cell Treatment or Hair Transplantation?

Hair stem cell therapy is not an alternative treatment method instead of hair transplantation. New hair should not be expected by giving stem cells to a completely bald area. However, by strengthening the extremely weak and undersized hair follicles, which we can call dormant, it can make the hair more dense. In completely bald areas, hair transplantation and stem cell therapy can be applied together.

TREATMENT OF HEART DISEASES WITH STEM CELL

In heart diseases, there is no treatment method that directly strengthens the heart muscle, except stem cell therapy, in the world. Different levels of improvement were measured in 87% of patients who received stem cell therapy for heart failure and ischemic heart disease.    • Stem cells have the ability to treat the vessels when they touch the problematic vessel wall, and if there is weakness in the heart muscles, they are used in the treatment of heart failure by transforming into heart muscle cells.

• The number of cells to be given is determined according to the age and weight of the patient.
• Treatment is carried out using endothelial, mesenchymal stem cells (obtained from the patient’s own adipose tissue or bone marrow) or fetal stem cell stem cells.
• Stem cells are given to the patient intravenously.

Heart Disease Treatment with Stem CellsStem cells have the ability to treat vessels when they touch the problematic vessel wall. At the same time, if there is weakness in the heart muscles, it is used in the treatment of heart failure by transforming into heart muscle cells.It accelerates the recovery process after surgery by strengthening the autoimmune system. Accelerates the treatment of heart muscle inflammation and inflammation.Endothelial (treating the vessels) stem cells are used for the vessel walls. However, mesenchymal or fetal stem cells are used together to treat other factors affecting the disease. In this way, the heart muscleautoimmune system and other factors are treated. The treatment of this disease can be done in our Cell Therapy Center.The number of cells to be transplanted is determined according to the age and weight of the patient. Treatment is carried out using endothelial, mesenchymal stem cells (derived from the patient’s own adipose tissue or bone marrow) or fetal stem cells. The decision is made according to the patient’s condition. It is performed in 3 sessions with 45-day intervals or by application for 2 consecutive days. It is given intravenously (through a vein).Various degrees of improvement were seen in 87% of patients with cardiovascular disease.

SKIN REJUVENATION TREATMENT WITH STEM CELL

Since the stem cells die in our skin at certain rates every year starting from the age of 28-30, we age and get wrinkles. It is possible to erase the negative effects of years and turn back time by replacing the lost cells with stem cell therapy.

• Cells taken from the person’s fat cells are multiplied in the laboratory environment and subjected to centrifugation processes, and then injected into the skin. Afterwards, it is given with small injections into the skin of the person in 3 separate cures with 1-month intervals.
• This treatment can be applied to all men and women over the age of 30.
• The procedure is unlikely to fail because it replaces the missing stem cells. The process does not differ from person to person. The number of stem cells in the skin is carried back to 8-10 years in each person who is treated. 

KIDNEY FAILURE TREATMENT WITH STEM CELL

Injection of stem cells promotes the germination of new vascular pathways, bypassing damaged ones, and also strengthens and restores poor functionality, repairs plaque-clogged vessels. On the one hand, with the stem cell injection, it restores the kidney tissue by restoring the kidney vessels.As a result of the treatment of chronic kidney disease using stem cells, when the treatment is started with early diagnosis, the biochemical parameters of blood and urine were normalized by stopping the progression of chronic kidney failure and restoring kidney function.

LYME TREATMENT WITH STEM CELL

With Stem Cell therapy, the progression of 350 different diseases caused by LYME disease can be slowed down and regressed. With the improvement to be achieved throughout the body, it significantly improves the patient’s quality of life by easing the immune system, muscle or joint-based symptoms caused by this disease.

• The treatment of LYME disease with stem cells is accepted as a new method that world scientists are working on.

• Stem cells have the ability to transform into damaged body cells (muscle, nerve, joint) when they touch them. Stem cells are therefore also used in the treatment of LYME disease.

• The number of cells to be given is determined according to the age and weight of the patient. The treatment can be performed in 3 sessions with 45-day intervals or 3 sessions with 1 week intervals.

• The treatment protocol is completely adjusted according to the patient’s condition, a different protocol is applied for each patient.

• The success rate of treatment increases significantly in early diagnosis. In studies, positive results have been obtained with stem cell therapy.

What is Lyme disease?

Lyme disease or Borreliosis is a disease caused by a bacterium called Borrelia burgdorferi and similar, which is usually transmitted to humans by the bite of Ixodes ricinus (Grill) ticks. Lyme disease is caused by the bacterium Borrelia burdorferi and is transmitted by the bite of infected ticks.Although the disease can occur in different forms, the first symptom is redness on the skin in the area of ​​​​the tick bite. Target organs may be organs such as the skin, central nervous system, eyes, and heart. There is swelling in the joints, fluid accumulation, and difficulty in movement.The disease can be treated with antibiotics. In some patients, the symptoms of the disease may persist for months or years after treatment. These symptoms may include muscle aches, arthritis, stiff neck, mental symptoms, nervous complaints, and extreme fatigue. It has also been found that the bacteria cause cancer.

What Are the Symptoms of Lyme disease?

Symptoms of a tick bite appear within 3-30 days.

• Fatigue, chills, fever, headache, muscle and joint pain and swelling of the lymph nodes are seen.

• A red rash, called erythema migrans (EM), is seen in the form of an expanding ring with the appearance of a “bull’s-eye”. It occurs in 70% of infected people and starts within 3-30 days (average 7 days) at the site of the tick bite.

• Some people may have a small lump or redness at the site of the tick bite, which disappears within 1-2 days. This is not a sign of lyme disease.If the patient is not treated at this stage, the infection can spread to other parts of the body within weeks and the following symptoms occur:

• Joint lesions in other areas of the body,

• Facial paralysis (loss of muscle tone on one or both sides of the face),

• Severe headache and neck stiffness due to meningitis,

• Pain and swelling in large joints,

• Heart palpitations and dizziness,Many of these symptoms disappear within weeks or months without treatment. However, untreated people may develop additional complications over months and years.

• Approximately 60% of patients may experience joint inflammation with intermittent severe joint pain and swelling. Large joints are affected, especially the knee joint.

• Up to 5% of patients have chronic central nervous system complaints.

• Approximately 10-20% of patients may experience recurrent symptoms lasting for months or years despite treatment with antibiotics. These are symptoms such as muscle and joint pain, sleep disorders, fatigue. The cause of these symptoms is not fully known. This is called “Post-Treatment Lyme disease syndrome.”

Causes of Lyme disease

Lyme disease is caused by the bacterium Borrelia burdorferi and is transmitted by the bite of infected ticks.

Although many mammalian species can be infected with this bacterium, deer are the most important reservoirs. Transmission occurs when adult or immature forms of infected Ixodes ticks bite humans. Most human infections are caused by being bitten by immature ticks. This is because immature ticks are less than 2 mm in size, making them difficult to detect on the body. They are generally more active in spring and summer. Adult ticks are more easily detected when they attach to the body, so they are more likely to be removed without transmitting the disease. Adult ticks are more active during the winter months.Ticks can bite any part of the human body. However, they are usually found in hard-to-see areas such as the groin, armpits, and scalp.

Lyme Disease Treatment

The diagnosis of Lyme disease is made based on the symptoms and physical examination findings and the history of exposure to the infected tick. Laboratory tests also help in diagnosis.Most cases of Lyme disease can be successfully treated with antibiotics in a few weeks. Patients treated with appropriate antibiotics in the early stages of Lyme disease usually recover quickly and completely.

Lyme Disease Treatment with Stem Cells

Stem cells have the ability to transform into damaged body cells (muscle, nerve, joint) when they touch them. Stem cells are therefore used in the treatment of LYME disease. It also treats damaged nerves and muscles. In this way, it can slow down the progress of the diseases caused by the bacteria, completely stop it and ensure its regression. The success rate of the treatment is directly proportional to the age of the patient, the duration of the disease and the current condition of the patient. If the disease is very advanced, more than one treatment may be required. For this reason, the success rate of treatment increases significantly in early diagnosis. Treatment can be performed in 3 sessions with an interval of 45 days or 3 sessions with an interval of 1 week.The number of cells to be given is determined according to the age and weight of the patient, and the treatment is carried out using mesenchymal stem cells (obtained from the patient’s own fat tissue or bone marrow) or fetal stem cells. The decision is made according to the patient’s condition. The success rate of treatment increases significantly in early diagnosis. In studies, positive results have been obtained with stem cell therapy. Although the number of people afflicted with this disease is not high, it has largely prevented the progression of the disease to more advanced stages in 95% of the patients receiving treatment and has helped to improve the existing bad situation.This treatment can be performed at our Clinic and Turkey Stem Cell Treatment Center in Istanbul, Turkey.  

FREQUENTLY ASKED QUESTIONS

Who is most affected by Lyme disease?

It is more common in people living in forested areas in Asia, eastern and western Europe, and the United States. The risk of infection is higher for campers in areas where it is common and for those traveling in mountainous areas.

Is Lyme a contagious disease?

This disease can be transmitted through blood transfusion, organ transplant or sexually. It is not transmitted through person-to-person contact, kissing or sexual intercourse.

How do I protect myself from Lyme disease?

A vaccine for Lyme disease has not been produced since 2002. Avoid tick-infested areas and ticks, and avoid direct contact with ticks. High grass and leaves, bushes and forest areas should be avoided. In such places, one should walk from the center of the roads.Repellents containing 20-30% DEET (N,N-diethyl-m-toluamide) should be used appropriately.Clothing and tent items containing 0.5% Permethrin should be used.If a tick is found attached to the skin, do not panic, the tick should be removed as quickly as possible. For this, fine-tipped tweezers should be used to grasp the tick as close to the surface of the skin as possible. When removing the tick, it should be lifted straight up without bending or shaking it. If a part of the skin, such as the mouth of the tick, remains, it should be tried to be removed with tweezers. If the remaining pieces cannot be easily removed, the skin should be left to heal.After removing the tick, the tick bite area and hands should be thoroughly cleaned with alcohol, iodine or soap and water.The tick should never be crushed with a finger.If a rash or fever develops within a few weeks of a tick removal, a doctor should be consulted. The doctor should be informed about the history of tick bite.

Does every tick bite cause Lyme disease?

Not every tick bite causes this disease. However, since the bacteria have many passageways, it has the potential to become an epidemic in the world today.Lyme bacteria can be transmitted from all blood-sucking creatures such as fleas and mosquitoes, apart from ticks, and can be found mostly in wild animals, mammals, birds, and cats and dogs in cities. 

TREATMENT OF AUTOIMMUNE DISEASES WITH STEM CELL

With Stem Cell therapy, the progression of autoimmune diseases can be slowed down, regressed or even completely stopped. The success rate of treatment is proportional to the age of the patient, the duration of the disease and the patient’s condition.

• The treatment of autoimmune diseases with stem cells is accepted as a new method that world scientists are working on.

• Stem cells have the ability to transform into damaged organs when they touch them, so they are used in the treatment of autoimmune diseases.

• Number of cells to be exported; determined by the age and weight of the patient. The treatment is carried out using mesenchymal stem cells (obtained from the patient’s own adipose tissue or bone marrow) or fetal stem cells.

• Which treatment will be applied is determined according to the patient’s condition. 3 sessions can be performed with an interval of 45 days or with an interval of 1 week. It is given intravenously (through a vein).

• The treatment protocol is completely adjusted according to the patient’s condition. A different protocol can be applied for each patient.

• The success rate of the treatment is directly proportional to the age of the patient and the duration of the disease. If the disease is very advanced, more than one stem cell treatment may be required. Success was achieved in 85% of the patients in the regression, cessation or complete treatment of the disease. However, 50% of the patients had to repeat the treatment within one year.

What are Autoimmune Diseases?

Autoimmune diseases occur as conditions in which the immune system attacks the body’s normal tissues. The immune system normally protects against microbes such as bacteria and viruses, and when it detects them, it immediately activates the defense cells. In an autoimmune disease, the immune system perceives various tissues and organs of the body, such as joints and skin, as foreign. For example, type 1 diabetes, an autoimmune disease, attacks the cells of the pancreas, and rheumatoid arthritis attacks the joints.The immune system is designed to protect our bodies against microbial invaders such as bacteria and viruses. When functioning properly, the immune system detects these microbial foreigners and sends a defensive force of warrior cells to surround and kill them. A healthy immune system knows the difference between foreign invaders and the body’s own cells, organs, and “good” microorganisms.

The most common autoimmune diseasesrheumatoid arthritisRheumatoid arthritis (RA) is an autoimmune disease that occurs because the immune system attacks the joints. This attack causes inflammation in the joints with pain, redness, swelling and temperature increase. Rheumatoid arthritis is a chronic disease and tends to start in the 30s.

Lupus (SLE)

Lupus occurs when the immune system perceives many tissues and organs of the body as foreign. Many organs are affected, including the skin, joints, kidneys, brain, and heart. Joint pain, weakness and skin rashes are the most common symptoms.DiabetesThe pancreas produces the hormone insulin, which helps regulate blood sugar levels. In type 1 diabetes, the immune system attacks and destroys the insulin-producing cells in the pancreas. As a result, the body cannot produce insulin, resulting in high blood sugar levels. high blood sugar; It damages various organs and tissues such as blood vessels, heart, kidneys, eyes and nerves.

Hashimoto

In Hashimoto’s disease, the thyroid gland is affected and thyroid hormone production is reduced. Symptoms include weight gain, intolerance to heat and cold, fatigue, hair loss, and goiter (enlargement of the thyroid gland). PsoriasisSkin cells normally grow and are shed when they are no longer needed. Psoriasis causes skin cells to multiply too quickly. Excess skin cells produced form a plaque or patchy rash on the skin covered with red, white scales.   Sjogren’s Syndrome

In Sjögren’s syndrome, the immune system attacks the joints and the tear and salivary glands. Significant symptoms of Sjögren’s syndrome are joint pain, dry eyes and mouth.

Familial Mediterranean Fever (FMF)

Familial Mediterranean fever is a genetic autoimmune disease that causes recurrent fever and painful inflammation of the abdomen, lungs, and joints. Pain, swelling, skin rashes and muscle aches in the joints are other important symptoms. Familial Mediterranean fever is caused by a gene mutation that is passed from parents to children.

Ankylosing spondylitis

Ankylosing spondylitis is an autoimmune disease that affects the spine. Spinal bones (vertebrae) stick together, creating limitation of movement in the spine. These changes can be mild or severe and result in a hunched posture. 

Behcet ‘s disease

Behcet ‘s disease; It is an autoimmune rheumatic disease with wounds in the mouth or genital area, redness and swelling in the eyes, inflammation in the joints, skin and digestive system problems. 

Multiple Sclerosis (MS)

Multiple sclerosis is a disease that occurs when the immune system attacks the protective myelin sheath that surrounds nerve cells. Damage to the myelin sheath affects message transmission between the brain and the body. This damage leads to symptoms such as lethargy, weakness, balance problems and difficulty walking. 

Celiac Disease

Celiac patients are hypersensitive to gluten, a protein found in grain products such as barley, wheat, and rye. The immune system, which attacks gluten, also damages the small intestine wall, causing inflammation. Symptoms such as diarrhea, abdominal pain, nausea, vomiting are seen.

What Are the Symptoms of Autoimmune Diseases?

There are more than 80 known autoimmune diseases, and some of them have very similar symptoms. This makes it difficult for doctors to diagnose whether or not a patient actually has one of these diseases.The hallmark of an autoimmune disease is inflammation that causes pain, redness, warmth, and swelling. The early symptoms of many autoimmune diseases are similar and may include:

•Tiredness

• Muscle pain

• Low body temperature

•Distractibility

• Numbness and tingling in hands and feet

•Hair loss• Skin rashes

• Swelling in the joints and other tissues

In addition, each disease can have its own specific symptoms.

For example, Type 1 diabetes causes extreme thirst, weight loss and urination, while inflammatory bowel disease causes abdominal pain, bloating and diarrhea.In some autoimmune diseases, such as psoriasis or rheumatoid arthritis, the symptoms get worse or disappear from time to time.

Causes of Autoimmune Diseases

The exact cause of autoimmune diseases is not known, but it is thought to be a common result of genetic and environmental factors. These diseases are more common in women than men.Some autoimmune diseases, such as multiple sclerosis and lupus, run in families. Not every family member necessarily has the same disease, but there is a predisposition to other autoimmune diseases.Because the incidence of autoimmune diseases is increasing day by day, researchers suspect that environmental factors such as infections, exposure to chemicals or solvents may also be involved. Eating foods high in fat, sugar, or processed foods can trigger an immune response, causing inflammation and triggering some autoimmune diseases. According to another theory, called the hygiene hypothesis, because of vaccines and antiseptics, children today are not as exposed to germs as they were in the past. This results in the immune system overreacting to harmless substances.

Treatment of Autoimmune Diseases

The treatments applied cannot cure autoimmune diseases, but they can control the overactive immune response and reduce inflammation. Treatments are also available to relieve symptoms such as pain, swelling, fatigue and skin rashes. Patients feel better with a special diet and regular exercise.

 Treatment of Autoimmune Diseases with Stem Cells

Stem cells have the ability to transform into these cells when they touch damaged organs, so they are used in the treatment of autoimmune diseases. It also treats damaged muscles and nerves. In this way, it can slow down the progression of the disease, completely stop it or make it regress. If the disease is very advanced, more than one treatment may be required. The success rate of the treatment is directly proportional to the age of the patient, the duration of the disease and the current condition of the patient.This treatment can be performed at our Clinic and Turkey Stem Cell Treatment Center in Istanbul, Turkey.

FREQUENTLY ASKED QUESTIONS

Autoimmune Diseases are most common in whom?

Autoimmune diseases are seen 2 to 1 more in women than in men. This means that 6.4% of women and 2.7% of men will be diagnosed with an autoimmune disease. In addition, there appears to be a relationship between autoimmunity and women of childbearing age. They are most often diagnosed in women, between the ages of 14 and 44. Certain autoimmune conditions are more likely to affect certain ethnic groups or families. Known as the “Western” diet, eating high-fat, high-sugar, highly processed and heat-treated foods can lead to autoimmunity and inflammation by generating an immune response and/or causing an increase in harmful bacteria and microbes in the gut.

What tests are used to diagnose Autoimmune Diseases?

Most autoimmune diseases cannot be diagnosed with a single test. Doctors make a diagnosis by combining physical examination findings with tests to make a diagnosis.The antinuclear antibody test (ANA) is often the first test used when symptoms indicate an autoimmune disease. A positive test result means that the person probably has one of these diseases, but it cannot determine exactly which one.Other tests are done by looking at the blood for specific autoantibodies produced in some autoimmune diseases. In addition, tests can be done to detect the inflammation that these diseases produce in the body.

What is recommended for autoimmune diseases?

Correcting the intestinal flora should be the first step. Balancing and regulating gut bacteria is very important. In addition, it is necessary to detect and correct heavy metal accumulation in the patient. For the examination, heavy metal levels can be checked only a few days a week in large centers. Reducing chronic stress and adding exercise to the patient’s life are also very important in these diseases.It is known that almost all autoimmune diseases are somehow related to nutrition, so the patient’s diet must be regulated in order to overcome the autoimmune disease process.It is essential to prefer fermented foods, to consume antioxidant-rich and live/fresh foods, to reduce dairy products, to consume anti-inflammatory foods, to consume sugar-containing foods (including fruit) and no packaged foods.In addition, it is recommended to avoid soy products, alcohol, legumes, seed oils (such as canola, sunflower, corn), nuts (can be consumed very limitedly), and foods containing gluten, which have allergen and immunostimulating properties.

Oligospermia (Low Sperm) Treatment with Stem Cells

Oligospermia can be treated with stem cell therapy, and it is possible to have a child with the desired sperm quality and number after the treatment in patients who cannot have children due to low sperm count. The success rate in patients who are suitable for treatment is 95% and above.

• Stem cells can transform into healthy cells they touch and reproduce them. In sperm deficiency disease, the stem cells given to the person transform into sperm cells, which are few in number, and allow them to multiply.

• Oligospermia treatment with stem cells can be applied to all adult men who have sperm cells, albeit in small numbers.

• Stem cells, which are separated from the stem cell-rich adipose tissue taken from the patient, are reproduced in the laboratory and given to the patient by intravenous route and/or by injection into the area where the physician deems appropriate.

• It is observed that patients who have not been able to have children for years due to lack of sperm after the treatment are able to have children.

What is Oligospermia (Low Sperm)?

What are the Symptoms of Oligospermia (Low Sperm)?

If an adult man cannot have a child even though he wants to and there is no problem with his partner, then the sperm count in the man is checked. Sperm deficiency does not show any symptoms in the body.

Oligospermia (Low Sperm) Grades

If the person has 10-15 million cells as a result of the test, it is graded as mild oligospermia, if there are 5-10 million cells, it is moderate oligospermia, and if there are less than 5 million cells as a result of the test, it is graded as high-grade oligospermia.

Causes of Oligospermia (Low Sperm):

Oligospermia can be seen due to unexplained and genetic disorders related to the testicles, not related to the testicles, resulting from the problems that occur later in the testis.Causes not related to testicles:Inadequate support to the testicles may be due to general habits, drugs, alcohol, smoking, insufficient vitamins and hormones, and the testicles may be physically damaged during activities such as horse riding and cycling. Hormone treatments that the person has seen or hypogonadism (sex hormone deprivation) caused by different reasons can also be counted among the causes not related to the testicles.

Causes related to testicles:

It is a situation where there is a lack of sperm due to the testicles, although there is no hormone disorder in patients with oligospermia. These are age-related decrease in sperm count, genetic disorder in Y chromosome, abnormal chromosome structure, disorder in USP 26 enzyme, abnormal growth in any body tissue (neoplasm), reproductive (genital) system structural differences, varicocele, swelling in the scrotum (hydrocele), past diseases such as mumps or malaria.

Causes that occur later in the testis:

These are the conditions that negatively affect the male reproductive (genital) system, which deteriorates after sperm production in the testis, and the quality of male sperm function due to ejaculation problems in men. Sperm deficiency can be seen in cases of infection or prostate problems, cystic fibrosis, obstruction in the ejaculate duct

Unexplained idiopathic oligospermia

Since 30% of men have an unexplained diagnosis of sperm deficiency or poor quality in the clinical or laboratory setting, the condition of patients with oligospermia in this group has been called idiopathic. Several factors such as age, infectious diseases (such as chlamydia infection), microdeletion syndrome, mitochondrial changes, environmental pollution, and hormonal changes may be in this 30% formation.In a study completed in 2013, it was observed that oligospermia and azoospermia diseases are significantly associated with being overweight or obese, but the cause is still unclear, even in thin patients.

5-Dna damage-induced oligospermia

Breast cancer susceptibility gene 2 (BRCA2) performs homologous recombination repair on damaged DNA during meiosis. Defects in this gene have been associated with severe oligospermia.

Oligospermia (Low Sperm) Treatment

Since the cause or causes of oligospermia disease are not known exactly, a healthy lifestyle and the process of completing the missing points diagnosed in the person is the starting point of specialist physicians.It is believed that herbal treatments can be a remedy as well as general expert advice such as healthy eating, regular exercise, quitting smoking, and staying away from toxic substances. Herbal treatments and testosterone increasing methods are preferred. Another natural treatment method is stem cell therapy.

Oligospermia (Low Sperm) Treatment with Stem Cells

In cases of oligospermia, semen analysis, genetic karyotype analysis and testicular biopsy sample may be requested to decide whether results can be obtained with simpler methods before stem cell therapy.Based on these findings, treatment options are evaluated. If the patient is found suitable for stem cell therapy, necessary blood tests are performed and then the treatment phase can be started.

Treatment Process :

Stem cells have the ability to transform into the cells they touch. Therefore, it is used in the treatment of oligospermia. If there are even a small number of sperm-forming cells, it touches them and increases the number of these cells, resulting in sperm formation.In patients without genetic disorders, stem cells obtained from the patient are given.If the patient is genetically ill with oligospermia, the patient is treated by giving stem cells that do not genetically carry this disorder. As a result of all tests, the type of stem cell to be given is decided. However, after the entire testicular structure is corrected, new sperm formation takes at least 72 days. Therefore, sperm production is expected at the earliest 6 months to 1 year after the treatment.The combination of all stages of sperm production and development is called ‘spermatogenesis’. Spermatogenesis includes the process from the stem cell stage of the sperm cell to becoming a mature sperm. This process is completed in 65-75 days. Understanding the stages of the spermatogenesis process and knowing how each stage affects the process is very important in order to decide how the treatment should be done.

Method of Application:

The number of cells to be transplanted is determined by the age and weight of the patient. The treatment is carried out using mesenchymal stem cells (obtained from the patient’s own adipose tissue or bone marrow) or fetal stem cells. Which treatment will be applied is decided according to the patient’s condition. 3 sessions with an interval of 45 days or 3 sessions with an interval of 1 week can be performed. The treatment protocol is completely adjusted according to the patient’s condition. A different protocol can be applied for each patient.The treatment of this disease can be done at our Clinic and Turkey Stem Cell Treatment Center in Istanbul, Turkey.

Success Rates in Oligospermia Treatment with Stem Cells

If there is even a small number of viable cells in the sperm producing cells in the testis, the success rate is 95% and above. The treatment can be repeated after 1 year to increase the number of sperm after formation. The time to evaluate sperm formation is at the earliest 6 months after treatment.

Frequently Asked Questions

Can stem cell therapy be applied to every patient in oligospermia?

If the patient does not receive cancer treatment and does not use cell-killing drugs, and if there are very few healthy sperm cells, stem cell therapy can be applied.

How many times can stem cell therapy be applied in oligospermia?

Since the treatment does not have any side effects, it can be applied as long as the person wants to increase the sperm count to ideal levels. While the treatment may give results in one go, it may need to be repeated in the following years.

Does stem cell therapy in oligospermia cause sexual reluctance?

Sexual reluctance is definitely not seen after stem cell treatment. On the contrary, since stem cell therapy is also used in the treatment of erectile dysfunction (erectile dysfunction), it may have positive effects on one’s sexual performance.

Ovarian Reserve Low (Infertility) Treatment with Stem Cells

The problem of low ovarian reserve (infertility) can be treated with stem cell therapy, using the patient’s own stem cells, without risk and without side effects.

• In case of ovarian reserve disorder, the person’s own stem cells reproduce healthy egg cells and compensate for the lack of ovarian reserve.

• It can be applied to all women with a complaint of low ovarian reserve.

• Stem cells taken from the patient are multiplied in the laboratory environment and given to the patient through the vein, the cells multiply the healthy ovarian cells they touch.

• Stem cell therapy success rate of low ovarian reserve is 67% and above.

What is Ovarian Reserve Low (Infertility)?

Ovarian reserve refers to the number of eggs in a woman’s ovaries. A woman with a high ovarian reserve has a high number of eggs (follicles).With the advancing age, especially after the age of 35, the ovarian reserve, that is, the follicles (eggs) that provide the woman’s fertility, begin to decrease. The fact that the number of eggs is more or less does not indicate whether the eggs of the woman are of good quality to give birth to a healthy baby.If a woman’s ovarian reserve is low but egg quality is high, her chances of conceiving are high. Likewise, the high number of ovarian reserve of a woman does not determine the quality of the egg. As a result, it is thought that the decrease in ovarian reserve is not related to egg quality. What are the Symptoms of Ovarian Reserve Low (Infertility)?Unwanted pregnancies, miscarriage and early menopause are among the symptoms of low ovarian reserve.

Causes of Low Ovarian Reserve (Infertility)

• A surgical treatment in ovarian tissue

• Cyst removal

• Any surgery

• Abscess

• Infection

• Chemotherapy started for any cancer

• Heavy smoking

• Caffeine intake Conditions such as these are important factors that reduce egg reserve. Decreased egg reserve reduces the rate of conception, makes it difficult to conceive and causes a decrease in egg quality

Ovarian Reserve Low (Infertility) Treatment

There is no known cure for duplication of the ovarian reserve. In general, the treatment applied to women with reduced reserves is IVF treatment in order not to waste time.If the woman is not very young or married, the collected eggs are frozen and stored for later use. In this way, even if the person enters menopause, he can receive IVF treatment in the future when he wants. If the goal is to delay menopause, the way to do it is with drugs.While the egg cell grows in the woman’s ovary, it produces estrogen and progesterone hormones. When the egg cell is depleted, the cells that enable the woman to become pregnant are depleted, estrogen and progesterone drugs taken from outside are given to the woman, and the woman has regular menstruation as if she is not in menopause, but cannot have a baby.Since there is no definite common treatment method, supportive drug treatments and intensive care treatments are applied occasionally. Another issue is a healthy and balanced diet, fluid consumption and maintaining an ideal weight.

Ovarian Reserve Low (Infertility) Treatment with Stem Cells

Stem cells are natural repairers that make up all the tissues and organs in our body, have the ability to transform into the cells they touch and divide unlimitedly, and can regenerate and heal our entire body. Therefore, it can be used in the treatment of infertility in women.The success rate in the treatment of the disease is directly proportional to the age of the patient, the duration of the disease and the current condition of the patient. Since the disease may originate from the endocrine system, all endocrinological examinations and tests should be performed.Endometriosis requires tubular or uterine structural disorders, adhesions, obstructions, gynecological diagnosis and intervention. However, other infertility diseases such as menstrual and ovulation disorders, polycystic ovary syndrome or the onset of menopause can be treated with stem cells. If all endocrinological treatments are completed, the success rate in increasing the quality and/or number of egg production in the ovary is 67% and above, depending on the condition of the person.

Method of Application:

The number of cells to be given; determined by the age and weight of the patient. The treatment is carried out using mesenchymal stem cells. Which treatment will be applied is decided according to the patient’s condition. 3 sessions with an interval of 45 days or 3 sessions with an interval of 1 week can be performed. While it is given intravenously (through a vein), a direct injection is made into the ovarian region at the same time.The treatment protocol is completely adjusted according to the patient’s condition. A different protocol can be applied for each patient. 

Success Rates in Treatment

If all endocrinological treatments are completed, the success rate in increasing the quality and/or number of eggs in the ovary is 67% and above.

Frequently Asked QuestionsIs the treatment of low ovarian reserve (infertility) with stem cells a painful treatment?

The treatment is completely painless. After a sufficient number of reproduction is achieved in the hospital environment, the patient is given intravenous (through a vein) and at the same time, a direct injection is made into the ovary region.

Can the treatment of low ovarian reserve (infertility) with stem cells be applied to every woman?

It can be applied to women of all ages if there is no endocrinological disease and/or treatment has been completed, if the patient does not receive cell-killing drugs or radiotherapy treatment.When should couples who cannot have children despite a regular relationship seek treatment?If the age of the woman is below 35 and there is no problem that may affect the formation of pregnancy, examination and treatment should be started after 1 year, after the age of 35, or after 6 months if there is a problem that may affect the formation of pregnancy in the past.

Cirrhosis, Liver Failure, Hepatic Encephalopathy Treatment with Stem Cells

With Stem Cell Therapy, liver tissue repair is provided in patients with cirrhosis – liver failure. The patient generally has a healthier state, increased liver function capacity of regenerated blood cells, decreased portal hypertension, which reduces the risk of bleeding, liver protein synthesis development, immune development, relief from complications and early relief from symptoms, and an increase in quality of life.• Stem cells are natural repairers that make up all tissues and organs in our body, have the ability to transform into cells they touch and divide unlimitedly, and can regenerate and heal our entire body. Therefore, they can be used in the treatment of cirrhosis.• In the early diagnosis stage of liver tissue repair with stem cell therapy, its success on cirrhosis and liver failure is over 95%.• The number of cells to be given is determined according to the age and weight of the patient. The treatment is carried out with 3 sessions with 45-day intervals or 3 consecutive days of application.

What is Cirrhosis, Liver Failure, Hepatic Encephalopathy?

Hepatic encephalopathy is a complex neuropsychiatric syndrome seen in patients with cirrhosis and similar liver dysfunction. Significant liver dysfunction includes acute liver failure, large portosystemic shunts, and cirrhosis. Hepatic encephalopathy is due to inadequate liver function and/or impaired liver perfusion.

What Are the Symptoms of Cirrhosis?

Cirrhosis usually does not show symptoms in the early stages. However, as the degree of the disease progresses and the level of damage to the liver increases, the symptoms and the severity of these symptoms increase. The most common symptoms of cirrhosis can be listed as follows:

• Appetite and weight loss

• Nausea and vomiting

• Constant feeling of fatigue

• Swelling- edema formation in the legs

• Swelling due to acid accumulation in the abdomen (in advanced cirrhosis)

• Muscle loss• Anemia

• Itching on the skin

• Jaundice in the eyes and skin

• Non-coagulation of the blood

• Menstrual irregularity in women

• Hypertension

• Spleen enlargement

• Bruising and bleeding on the skin

• Irritability

• Constipation and gas problem

• Feeling of heaviness in the stomach

Causes of Cirrhosis

The most common known cause of cirrhosis is chronic alcohol use. Apart from excessive alcohol use, one of the most important causes of cirrhosis is chronic viral hepatitis such as Hepatitis B and Hepatitis C. In approximately 10-15% of cirrhosis patients, no obvious cause can be found despite all the researches, and this condition is called cirrhosis of unknown origin (cryptogenic cirrhosis).Apart from these, people may develop cirrhosis, albeit rarely, for the following reasons:• Non-alcoholic fatty liver disease• Obstruction and inflammation of the bile ducts• Autoimmune hepatitis caused by the body’s production of antibodies against its own tissues• Long-term use of heavy drugs• Excessive intake of iron and copper minerals• Chronic heart failure

Treatment of Cirrhosis and Hepatic Encephalopathy Disease

The diagnosis of hepatic encephalopathy is clinical and is based on identification of significant liver dysfunction, exclusion of other causes of encephalopathy, and grading of hepatic encephalopathy severity. The care of hepatic encephalopathy requires a simultaneous approach from four branches:

1. Supportive measures for the patient with a change in mental status,

2. Exclusion of other causes of encephalopathy,

3. Identification and treatment of facilitating factors,

4. Implementation of empirical therapy.Liver transplantation is the only radical treatment for liver cirrhosis because structural changes cannot be reversed. However, the progression of cirrhosis can be stopped by discontinuing alcohol if the cause of liver cirrhosis is alcohol use, initiating antiviral drugs for viral hepatitis, or by using immunosuppressive drugs if autoimmune hepatitis 

Cirrhosis Treatment with Stem Cells

When stem cells touch damaged liver cells, they have the ability to transform into these cells. Therefore, it is used in the treatment of liver dysfunction. In this way, it can slow down the progression of the disease, completely stop it and ensure its regression. The success rate of the treatment is directly proportional to the age of the patient, the duration of the disease and the current condition of the patient. In cases where the disease is very advanced, treatment is not possible in case the liver is in such a bad condition that it cannot be repaired or the patient dies before the cells can renew themselves.On the other hand, stem cell therapy is not applied in cases where the disease is due to the hepatitis C virus, since it is a viral condition.

Results of liver tissue repair with stem cell therapy:

• Transformation to a healthier overall

• Increasing the liver function capacity of regenerated blood cells

• Coping with the disease itself

• Reduction of portal hypertension, which reduces the risk of bleeding

• Improvement of liver protein synthesis

• Immune development

• Getting rid of complications and getting rid of their symptoms early

• Increase in quality of life, hope for a longer lifeThe treatment of this disease can be done at our Clinic and Turkey Stem Cell Treatment Center in Turkey, Istanbul.

Method of Application:

The treatment protocol is determined according to the current condition of the patient. The number of cells to be transplanted is based on the age and weight of the patient. The treatment is carried out using mesenchymal stem cells. Which treatment will be applied is decided according to the patient’s condition. 3 sessions with an interval of 45 days or 3 sessions with an interval of 1 week can be performed. While it is given intravenously (through a vein), a certain amount is injected into the vein that goes to the liver at the same time. Fetal stem cells are generally preferred because fat removal is not possible in severe cirrhosis cases.The treatment protocol is completely adjusted according to the patient’s condition. A different protocol can be applied for each patient.

LUPUS Disease (SLE) Treatment with Stem Cells

With Stem Cell therapy, the progression of LUPUS can be slowed down, regressed or even completely stopped. The success rate of treatment is proportional to the age of the patient, the duration of the disease and the patient’s condition.

• The treatment of LUPUS disease with stem cells is accepted as a new method that world scientists are working on.

• Stem cells have the ability to transform into damaged organs when they touch them, so they are used in the treatment of lupus.

• Number of cells to be exported; determined by the age and weight of the patient. The treatment is carried out using mesenchymal stem cells (obtained from the patient’s own adipose tissue or bone marrow) or Fetal stem cells.

• Which treatment will be applied is decided according to the patient’s condition. It can be performed in 3 sessions with 45-day intervals or by application for 3 consecutive days. It is given intravenously (through a vein)

• The treatment protocol is completely adjusted according to the patient’s condition. A different protocol can be applied for each patient.

• The success rate of the treatment is directly proportional to the age of the patient and the duration of the disease. If the disease is very advanced, more than one stem cell treatment may be required. 99% success has been achieved in the regression, cessation or complete treatment of the disease. However, 60% of the patients had to repeat the treatment within one year.

What is LUPUS Disease?

Systemic Lupus Erythematosus (SLE) is an autoimmune disease, the cause of which is unknown. It occurs as a result of the malfunctioning of the immune system and can affect every organ, but it is mostly seen in the skin, joints, kidneys, blood cells and nervous system.Systemic lupus erythematosus (SLE) is an inflammatory and chronic disease. It progresses with exacerbations and regressions. Treatment depends on disease severity. It requires regular observation. Although the exact cause is unknown, genetic and environmental effects have been identified. Sun sensitivity is one of the known skin symptoms.It is seen 9 times more frequently in women than in men, and it mostly affects women aged 15-45 years, that is, women of childbearing age. It is thought that hormonal factors also play a role in the development of SLE, which can be seen at earlier and later ages, albeit to a lesser extent. Lupus patients should be careful about the risk of infection and coronary heart disease and should be protected from the sun.As with many diseases, it is known that various environmental factors such as sunlight, viruses, chemicals, foods and drugs also play a triggering role in individuals with genetic predisposition.

What are the Symptoms of LUPUS Disease?

• SLE is a disease that progresses with periods of exacerbation and remission. Red rashes may occur on the skin, which becomes evident with hypersensitivity to the sun. This rash that looks like a butterfly shape on the face and rashes that can leave marks on other parts of the body can also be seen.• At the beginning of the disease and during the active period, symptoms such as weakness, loss of appetite, fever and weight loss that are not related to a specific disease and can be seen during the course of many systemic diseases may occur.• In some patients, whitening-bruising may be detected on the fingertips. Apart from common muscle pain, patients may experience joint pain and joint swelling that does not cause permanent damage to the joint.• Kidneys are the target organ system of the disease, this effect can be seen in about half of the patients. Some patients may develop edema of the legs associated with protein loss. It is important to recognize and treat the disease at an early stage. Otherwise, kidney failure and the need for dialysis may occur in some patients.• It can cause inflammation between the membranes surrounding the heart and lungs, causing symptoms in the form of flank pain that increases with breathing or coughing. Inflammation may occur in the layers of the heart, as well as valve involvement.• Affecting the central nervous system may present as headache, convulsions in seizures, and sometimes as a symptom of illness or psychosis due to high-dose cortisone treatment.• SLE can affect both the central and peripheral nervous systems. Weakness in the hands and feet and loss of function in some patients are examples of peripheral nerve involvement findings of the disease.• Vasculitis (inflammation of the vessel wall) may accompany active SLE, and many organs may be affected for this reason. The functions of the affected organs may be impaired due to vasculitis. In approximately 10% of patients, occlusions due to coagulation may also develop in the vein.

Causes of LUPUS Disease

The root cause of this disease or what causes it is not yet known exactly. Lupus means “wolf” in Latin. SLE disease, which is a type of lupus disease, stands for “Systemic lupus erythematosus”. It is thought that genetically predisposed individuals and environmental factors play a role in the onset and maintenance of SLE.Systemic Lupus Erythematosus (SLE) or diffuse lupus redness is a disease of unknown origin, manifested by multiple findings related to inflammation of many tissues and organs such as skin, joints, kidneys, pericardium, pleura, and manifests as a result of impaired immune system functioning.

 LUPUS Disease Treatment

There is no definitive treatment for lupus disease. Treatment is applied to stop the progression of the disease, prevent vital complications and alleviate symptoms, and early diagnosis is of great importance because it is not possible to reverse advanced disease.Anti-inflammatory drugs are used for inflammation in many organs and tissues of the body. Steroid group drugs that suppress the immune system, blood thinning agents such as aspirin are also preferred for patients with a tendency to blood clot.

LUPUS Disease Treatment with Stem Cells

Since the disease is caused by a gene defect, stem cells obtained from baby cord or fetus can be applied to the patient. It can be used if it is ensured that the disease is not transmitted to the stem cells obtained from the patient himself. Stem cells have the ability to transform into these cells when they touch damaged organs, so they are used in the treatment of lupus.It also treats damaged muscles and nerves. In this way, it can slow down the progression of the disease, completely stop it or make it regress. If the disease is very advanced, more than one treatment may be required. The success rate of the treatment is directly proportional to the age of the patient, the duration of the disease and the current condition of the patient.This treatment can be done at our Clınıc and Turkey stem cell treatment center in İstanbul, Turkey.

FREQUENTLY ASKED QUESTIONS

In whom is LUPUS disease most common?

The disease, which is most commonly seen between the ages of 15-45, is not contagious, mostly seen in women. The percentage of pediatric patients is very low. In addition, some drugs are thought to exacerbate or exacerbate the disease. Ultraviolet-A and B rays, birth control pills, estrogen hormones, pregnancy and environmental conditions can also trigger the disease.

What Are the Types of LUPUS Disease?

Lupus can occur in 6 different types,Systemic Lupus Erythematosus (SLE):

It accounts for 70 percent of lupus cases. The most common type is SLE.Chronic Cutaneous Lupus Erythematosus:It accounts for up to 10 percent of lupus cases. They are lesions in the form of prominent plaques, most often on the scalp on the face and less frequently on the arms and trunk.

Subacute Cutaneous Lupus Erythematosus:

It is limited to the skin but transforms to SLE at a rate of 30-50% over time. Here, skin rashes and psoriasis-like lesions occur in many parts of the body.Drug-Associated Lupus:It is a picture that develops due to many drugs and chemicals, and usually resolves with discontinuation of the relevant drug or with short-term treatments.

Neonatal Lupus (Neonatal Lupus):

It is a type that develops from birth in the baby of a pregnant patient with SLE and generally resolves within the first 6-8 months.Overlap Syndromes:It is the condition of having signs of lupus with another disease.

 Is LUPUS a Genetic (Hereditary) Disease?

SLE can be inherited. Children can inherit certain as yet unknown genetic factors that predispose them to develop SLE from their parents.

How is LUPUS Diagnosed?

The diagnosis of SLE must be made by a doctor experienced in this disease. Diagnosis; It is determined as a result of the evaluation of the symptoms of the disease and the findings obtained from the blood or tissue. 

Cerebral Palsy (CP) Disease Treatment with Stem Cells

In patients with cerebral palsy, stem cell therapy provides healing in damaged brain cells, nerve and muscle cells. Preventing and minimizing the disorders increases the patient’s quality of life at home and in the community, and reduces the problems associated with the disease.• Stem cells are used in the treatment of Cerebral Palsy, thanks to their ability to transform damaged brain cells when touched, and to treat damaged nerves and muscles.• This treatment slows down the progression of the disease, can stop it completely and make it regress.• The number of cells to be given is determined according to the age and weight of the patient. The treatment can be performed in 3 sessions with 45-day intervals or 3 sessions with 1 week intervals.• The success rate is related to the age of the patient, the duration of the disease and the current condition of the patient. In very advanced cases, more than one treatment may be required. What is Cerebral Palsy (CP) Disease?Cerebral Palsy is a physical disability caused by damage to the immature brain in the prenatal, perinatal or postnatal period. Although the disease affects muscle movements, it is not caused by a problem in the muscles or nerves. Abnormalities in the areas of the brain that control muscle movements cause cerebral palsy.It is not a disease that progresses over time. Significant improvements can be achieved with early intervention in the traumatized brain and various lifelong rehabilitation practices and treatments. What are the Symptoms of Cerebral Palsy (CP) Disease?Most children with cerebral palsy are born with the disorder, but the disorder may go undetected for months or years. Symptoms of the disease can affect the whole body or one side of the body.This disease should be suspected especially in children between 0-12 months who have weakness or difference in motor movements, muscle weakness, joint and postural disorders, difficulty in adapting to social life, and unable to engage in activities independently.Babies with CP reach developmental milestones such as turning, sitting, crawling, or walking later than their peers. They may have reflexes that should normally disappear in the early infant.

The main symptoms of the disease are:

• Delays in motor skill development such as rolling, sitting alone or crawling

• Changes in muscle tone, such as excessive stiffness or looseness

• Visual, hearing and speech disorders

• Neurological problems such as seizures, intellectual disability and blindness

• Stiffness and exaggerated reflexes called spasticity in the muscles

• Weakness of muscle coordination called ataxia

• Respiratory disorders

• Bladder and intestinal disorders

• Shaking and involuntary movements

• Frequent falls• Swallowing problems

• Preferring one side of the body, for example always holding objects with the same hand

Causes of Cerebral Palsy (CP) Disease

Some of the risk factors that cause this disease are:

• Blood incompatibility between mother and baby• The baby’s lack of oxygen during pregnancy or birth• During pregnancy, the mother has a viral or bacterial infection that will affect the baby’s nervous system.• Alcohol, drugs or drugs used during pregnancy• Premature birth• Low birth weight• Blood clotting problems• Brain hemorrhages

• Treatment of Cerebral Palsy (CP) Disease

Treatment is focused on preventing or minimizing deformities and improving the patient’s quality of life at home and in the community. Children and adults with cerebral palsy need long-term treatment with a medical care team. These treatments encompass a variety of surgical and non-surgical alternatives.

Non-surgical treatments

• Rehabilitation
• Position assistance: Applied to help the child sit, lie down or stand.
• Orthoses and splints: They are applied to prevent, provide support or protect the deformity.
• Medication: These are applications given orally or by injection to control seizures or reduce spasticity in the muscles..

Surgical treatments:Orthopedic surgery:Hip dislocation, ankle and foot deformities and muscle contractures.Neurosurgery:Selective dorsal rhizotomy and intrathecal baclofen pump to correct spasticity.

Cerebral Palsy (CP) Disease Treatment with Stem Cells

Stem cells have the ability to transform into damaged brain cells when they touch them. For this reason, they are used in the treatment of Cerebral Palsy. Likewise, they treat damaged nerves and muscles. Thus, they can slow down the progression of the disease, completely stop it and ensure its regression. The success rate of the treatment is directly proportional to the age of the patient, the duration of the disease and the current condition of the patient. If the disease is very advanced, more than one treatment may be required. The treatment of this disease can be done at our Cilinc and Turkey Stem Cell Treatment Center in Istanbul, Turkey. 

Method of Application:

The number of cells to be transplanted is determined by the age and weight of the patient. The treatment is carried out using mesenchymal stem cells. Which treatment will be applied is decided according to the patient’s condition. 3 sessions with an interval of 45 days or 3 sessions with an interval of 1 week can be performed. The treatment protocol is completely adjusted according to the patient’s condition, a different protocol can be applied for each patient.

Frequently Asked Questions

What is the Success Rate of Stem Cell Therapy in Cerebral Palsy?

Although the success of the treatment varies according to the age of the patient and the degree of the disease, the success rate in the disease varies between 43% and 87%.

How is Cerebral Palsy Diagnosed and Diagnosed?

The diagnosis of CP is made by physical examination. During the examination, the doctor learns the full prenatal and birth history of the child. The diagnosis of CP is usually not made until the child is 6 to 12 months old. This is the period when the child should reach developmental milestones such as walking, hand and head control.

The following diagnostic tests can be used to diagnose the disease:

• Neurological examination: It can be done to evaluate reflexes and brain-motor functions.

• X-ray: It can be used to see abnormalities in internal tissues, bones and organs.

• Electroencephalogram (EEG): It is a process in which the electrical activities of the brain are continuously recorded with electrodes placed on the skull.

• Gait examinations: Can be applied to assess the child’s gait pattern.

• Magnetic Resonance Imaging (MRI): It can be used in cases where x-rays are insufficient by creating detailed images of organs and structures inside the body.

• Computed Tomography Scan (CT): It is a diagnostic imaging method that uses a combination of x-rays and computer technology to create both horizontal and vertical cross-sectional images of the body. A CT scan shows detailed images of any part of the body that includes bones, muscles, fat, and organs.

• Genetic studies: These are diagnostic tests that evaluate familial transmission conditions.

• Metabolic tests and blood tests can also be used in the diagnosis phase.

What are the types of Cerebral Palsy?

Spastic:It occurs due to damage to the motor cortex, the muscles are stiff with movement restriction. It is the most common variety with a rate of 70-80%.Ataxic:Occurs due to cerebellar injury. It affects the patient’s balance-position status.Dyskinetic:It is caused by damage to the Basal Ganglion. It is the least common type.

Ulcerative Colitis Treatment with Stem Cells

With Stem Cell therapy, the progression of ULCERATIVE COLITIS can be slowed down, regressed or even completely stopped. The success rate of treatment is proportional to the age of the patient, the duration of the disease and the patient’s condition.

• Treatment of ULCERATIVE COLITIS with stem cells is accepted as a new method on which world scientists are working.

• Stem cells are basically obtained from bone marrow, adipose tissue and fetal (the structure that emerges when the egg is fertilized with sperm). In the operating room, a small amount of sample is taken from the person’s own fat tissue with the liposuction method, and the necessary stem cells are separated in laboratories approved by the Ministry of Health.

• Stem cells obtained from the person’s own tissues are injected either systemically through a vein or by injecting them directly into the tissue or organ in a more targeted way. A success of over 90% is achieved with the appropriate treatment method for the appropriate patient by passing through a good test and analysis stage.

What is ULCERATIVE COLITIS?

Ulcerative colitis, an inflammatory bowel disease, is a long-term, chronic disease seen in the digestive tract. In this disease, some changes occur in the layer covering the inner surface of the digestive tract, depending on the severity of the disease, the cause is an inflammatory reaction (inflammation). This inflammatory reaction mostly occurs on the inner surface of the intestine and progresses with ulcers, swelling, injury, bleeding and irritation in the layer (mucosa) that covers the inner surface of the intestine.The disease is called ulcerative colitis, which means a disease characterized by ulcers, due to ulcers in the mucosa, which is the covering layer that covers the inner surface of the intestine, in the area where the inflammatory change occurs.The rectum and left colon (the last part of the large intestine) are most commonly affected in the large intestine (intestine). Other parts of the digestive tract (intestinal tract) (eg: stomach, small intestine) are not affected.There are two different types of inflammatory bowel disease: Ulcerative Colitis and Crohn’s Disease. Apart from these, there is another type that is not similar to both types, is in between, and cannot be determined.

What are the Symptoms of Ulcerative Colitis Disease?

Ulcerative colitis is a disease that only affects the large intestine. Different names are given to the place of involvement of the disease. For this reason, different names are used, which mean the same as inflammatory bowel disease and express the part of the intestine affected by the disease.Involvement of the large intestine is called colitis for short. In addition, affecting the entire large intestine is called pancolitis, affecting only the descending colon is called left colitis, and affecting the rectum, which is the last part of the large intestine, is called proctitis. The patient’s complaints vary according to the region affected by the disease.During the course of ulcerative colitis, problems related to the digestive tract may develop due to the disease, as well as problems involving organs other than the digestive tract.Ulcerative colitis is also classified according to the region it affects. Local (regional) only if it concerns the digestive – intestinal tract; If it concerns other organs or the whole body other than the intestinal tract, it is called systemic (extratestinal) involvement.

Regional Effects

• Serious bleeding from deep ulcers, intestinal perforation, enlargement of the intestine and cessation of bowel movements (toxic megacolon, toxic dilatation) are among the most obvious effects. The most serious of these local complications is toxic megacolon.

• Sudden severe swelling in the abdomen, fever, constipation and poor general condition are the harbingers of this complication. As a result of inflammation involving the entire colon wall, the large intestine becomes thinner, enlarged, and may even perforate

Systemic (Extra-intestinal) effects

Extraintestinal Findings:Substances secreted in the disease also affect distant organs. These include fever, weight loss, weakness and decreased appetite. In some patients, joint, skin, eye and liver disorders are observed.

Ulcerative Colitis Joint Findings:It causes inflammation (arthritis) in the distal (end) joints. In some patients, the lower spine and pelvis joints (sacroiliac joint) are affected. Small joints in the fingers, hands, feet, wrists and knees are most affected. The more severe form affecting the joint spaces in the spine is called ankylosing spondylitis.

lcerative Colitis Skin Findings:Red bumps may develop under the skin. These are nodules on the skin and are tender by pressing on it.

Pyoderma Gangrenosum:They are purulent skin sores that develop with deep ulcers. It also settles in the same regions. The third skin finding is painful superficial ulcers in the mouth called aphthous stomatitis. It is often located between the lower lip and gums, on both sides of the tongue and at the root of the tongue. When the intestinal disease is healed, three problems are resolved.

Ulcerative Colitis Eye Findings:Some patients complain of uveitis, which is a painful inflammation of the eye. When the intestinal findings improve, this situation also improves.

Ulcerative Colitis Liver Findings:Inflammatory changes (inflammation) may develop in the bile ducts and liver. While the inflammation observed in the liver improves with intestinal inflammation, sclerosing cholangitis affecting the biliary tract does not. Although rare, biliary tract cancer may develop.

Causes of Ulcerative Colitis

The exact cause of ulcerative colitis is not known, but in recent years, theories have been put forward that it is an immune system disease. The disease may show hereditary transmission. For example, a child with a family history of ulcerative colitis is more likely to have this disease than children from healthy families.The disease is not contagious. Among environmental factors, smoking and alcohol consumption are thought to be quite effective. Aspirin, antibiotics, birth control pills can lead to further aggravation of the disease. Different theories suggest that a virus or bacterium (microbial) initiates immune system-related (immunological) events in the intestinal wall.

Ulcerative Colitis Treatment

There is no treatment that completely eradicates the disease. Oral pills or enemas or suppository drugs administered through the anus into the intestine are preferred for treatment. With early discontinuation of treatment, the disease may flare up again. Therefore, treatment should be long-term (lifelong). In this way, the recurrence of the disease is prevented. The complete disappearance of the disease is only possible with the surgical removal of the sick intestine

Ulcerative Colitis Treatment with Stem Cells

Although it is not certain that the disease is of genetic origin, Mesenchymal stem cells with a non-genetic structure can be applied. Stem cell therapy slows the progression of the disease as it strengthens the body’s defense system. With the strengthening of the body’s defense system, the inflammation begins to dry up. In this way, it can slow down the progression of the disease, completely stop it and ensure its regression. The success rate of the treatment is directly proportional to the age of the patient, the duration of the disease and the current condition of the patient. If the disease is very advanced, more than one treatment may be required. Stem cells are given either systemically through a vein or by injecting them directly into the tissue or organ in a more targeted way.This treatment can be performed at our Clinic and Turkey Stem Cell Treatment Center in Istanbul, Turkey.

Success Rate in Treatment:

A success of over 90% is achieved with the appropriate treatment method for the appropriate patient by passing through a good test and analysis stage.

FREQUENTLY ASKED QUESTIONS

Ulcerative colitis Is it a genetic (hereditary) disease?

It is known to occur more frequently in some families. In 20% of patients, first-degree relatives are also affected by the disease. On the other hand, there is no definite transition determined until today, but it is possible to say that there is a tendency. For example; The risk in children with both parents with inflammatory bowel disease may be as high as 36%.

How is ULCERATIVE COLIT Diagnosed?

The most important diagnostic method is the doctor’s evaluation and examination of the patient. In addition, some tests are required for a definitive diagnosis.

• Examination should be made for some bacteria and amoeba (parasite), especially in stool. Because some bacteria such as shigella and some parasites such as Entamoeba histolityca can cause ulcerative colitis-like picture.

• Anemia, white blood cell elevation and sedimentation elevation can be seen. Anemia (low hemoglobin – anemia) occurs due to bleeding. White blood cell and sedimentation elevation reflect the severity of the inflammation (inflammation) event.

• If the patient’s symptoms suggest ulcerative colitis, the lining (mucosa) of the large intestine should be examined. With a special device placed through the rectum (anus), the doctor can see the layer that covers the large intestine and the inside of the rectum and can take a sample (biopsy) from the area of ​​the disease to examine under the microscope. With this examination, other factors with signs and symptoms similar to those of inflammatory bowel disease can be detected.

• An idea about the type and spread of the disease can be obtained by taking a medicated film of the large intestine (double contrast colon radiography, barium enema). Differential diagnosis of other diseases that cause similar symptoms can be made by performing blood count and amoeba examination in stool

How is ULCERATIVE COLIT Diagnosed?

The most important diagnostic method is the doctor’s evaluation and examination of the patient. In addition, some tests are required for a definitive diagnosis.

• Examination should be made for some bacteria and amoeba (parasite), especially in stool. Because some bacteria such as shigella and some parasites such as Entamoeba histolityca can cause ulcerative colitis-like picture.

• Anemia, white blood cell elevation and sedimentation elevation can be seen. Anemia (low hemoglobin – anemia) occurs due to bleeding. White blood cell and sedimentation elevation reflect the severity of the inflammation (inflammation) event.

• If the patient’s symptoms suggest ulcerative colitis, the lining (mucosa) of the large intestine should be examined. With a special device placed through the rectum (anus), the doctor can see the layer that covers the large intestine and the inside of the rectum and can take a sample (biopsy) from the area of ​​the disease to examine under the microscope .

With this examination, other factors with signs and symptoms similar to those of inflammatory bowel can be detected.

• An idea about the type and spread of the disease can be obtained by taking a medicated film of the large intestine (double contrast colon radiography, barium enema). Differential diagnosis of other diseases that cause similar symptoms can be made by performing blood count and amoeba examination in stool

What is Stroke and Cerebral Palsy & How Is It Treated With Stem Cells?

Stroke, also known as “paralysis”, usually occurs with the sudden interruption of the blood flow that provides the oxygen and sugar needs of a part of the brain, and sometimes with bleeding into the brain tissue. There are also those who call this a ‘brain attack’, inspired by a heart attack. In this case, temporary or permanent damage occurs in brain cells.Permanent damage to cells can lead to permanent loss of function in the part of the body controlled by these cells; For example, when cells that control movement function in the right brain are damaged, a complete or partial stroke occurs on the left side of our body, causing weakness in the arms and legs.

Stroke Symptoms:

Weakness on one or both sides of the body: Often occurs in the arms, legs, hands, and face. One of the arms and legs is usually affected on the right or left side.Loss of sensation on one or both sides of the body: Some people may experience numbness, numbness and a pins-and-needles sensation in a part of the body.Speech difficulties: the stroke survivor has difficulty speaking, slurring, or sometimes finding the right words. Some people have difficulty understanding what is being said.Changes in consciousness: Loss of consciousness, sleepiness, not being able to notice the surroundings, not understanding the questions asked and what is wanted to be done can be seen.Visual disturbances: In stroke, double vision, loss of vision in one eye, right or left visual field may occur.Sudden headache: Sudden headache of unknown cause, Dizziness, nausea, vomiting and balance problems may occur.

Current Stroke-Stroke-Brain Stroke Treatments:

Intravenous Thrombolysis: In the emergency treatment of stroke, rapid correction of cerebral blood flow, which is impaired due to occlusion of the vessel feeding the brain, is required. In treatment, every minute from the moment the stroke occurs is very important. Intravenous anticoagulant drug therapy (intravenous thrombolytic therapy) is the administration of an intravenous anticoagulant drug that can be administered within 4.5 hours at the latest after the onset of paralysis symptoms. For this purpose, recombinant tissue plasminogen activator (rtPA) produced by genetic engineering is used as a drug. Ideally, it should be done as soon as possible. This treatment dissolves the clot and helps to improve blood flow quickly and effectively, thereby improving the stroke. If the patient’s condition is not suitable for the application of this treatment or if the time period since the occurrence of the stroke is prolonged, intravenous clot-dissolving treatment cannot be applied. Your doctor will refer to other drugs and methods in treatment.

Endovascular Treatments: If the main vessels feeding the brain are clogged with clots, intravenous thrombolysis treatment is not sufficient to dissolve the clot mass in these large vessels. In this case, the main purpose of treatment is to dissolve the clot in the vein or to remove it from the vein. Treatments for this purpose are called endovascular or interventional treatments and are performed through angiography.This treatment method should be applied in the first 8 hours after the onset of stroke.

Intra-arterial Clot Dissolving Drug Treatment (Intraarterial Thrombolysis): With the angiographic method, a thin and flexible catheter is entered into the artery from the groin. rtPA is applied directly. Today, this method is generally an auxiliary treatment method.

Mechanical Clot Removal Treatment (Thrombectomy): With the angiographic method, a thin and flexible catheter is entered from the groin into the artery, where the occluded vein causing the stroke and the clot occluded are reached by advancing towards the vessels feeding the brain. The clot blocking the vein is removed from the vein by suction (aspiration) or with special retractable stents and removed from the vein.

Stem Cell Treatment Method

Stem cells have the ability to transform into cells they touch, such as nerve, brain and muscle, so they are used in the treatment of cerebral palsy. The stem cells transplanted to the patient are stem cells that do not genetically carry this disorder. Therefore, it replaces the damaged cells. The body’s defense system is strengthened and the swelling of the vessels in the neck and brain area is completely prevented or reduced. In this way, it can slow down the progression of the disease, completely stop it and ensure its regression. The success rate of the treatment is directly proportional to the age of the patient, the duration of the disease and the current condition of the patient. If the disease is very advanced, more than one treatment may be required.The first goal in the treatment of cerebral palsy is to prevent further progression of the disease and to take measures accordingly. Physical therapy is the most common and most appropriate treatment method. Thanks to the exercises, the joints of the patient that cannot be moved are softened and after a while, they are enabled to move more easily. Physical therapy should be carried out on a regular basis. It may force the patient from time to time, but if it is done regularly, the result is definitely obtained. Joint movements are seen more clearly and a significant progress is made in movement compared to the past.Medication is administered if deemed appropriate. Drug treatments do not prevent the application of stem cell therapy. The drugs used to soften the patient’s hardening and hardening joints are a preparatory stage for therapy. If we talk about surgical intervention, the surgeries are not risky and show signs of recovery in a short time. Disorders in the joints are repaired in a short time and significant progress is made in movement. The treatment of this disease can be done at our Clinic and Turkey treatment center in Istanbul, Turkey.

Method of Application:

The number of cells to be given; determined by the age and weight of the patient. The treatment is carried out using mesenchymal stem cells. Which treatment will be applied is decided according to the patient’s condition. 3 sessions with an interval of 45 days or 3 sessions with an interval of 1 week can be performed. While it is given intravenously (through a vein), a certain amount of injection into the vein going to the brain may be preferred at the same time.The treatment protocol is completely adjusted according to the patient’s condition. A different protocol can be applied for each patient.

Success Rates in Treatment

The size of the given stem cells is small enough to pass through the brain cells. For this reason, the success rate of treatment increases significantly in early diagnosis. In studies, very positive results have been obtained with stem cell therapy. It greatly prevented the progression of the disease to more advanced stages in 79% of the patients and helped to improve the existing bad situation

TREATMENT OF DEMENTIA WITH STEM CELL

With Stem Cell therapy, the progression of DEMENTS can be slowed down and regressed. The success rate of treatment is proportional to the age of the patient, the duration of the disease and the patient’s condition.

• Treatment of dementia with stem cells is accepted as a new method that world scientists are working on.

• Stem cells have the ability to transform into damaged brain cells when they touch them. Stem cells are therefore dementiaused in the treatment.

• The number of cells to be given is determined according to the age and weight of the patient. The treatment is carried out in 3 sessions with 45-day intervals or 3 consecutive days of application.

• The size of the stem cells given is small enough to pass through the brain cells. For this reason, the success rate of treatment increases significantly in early diagnosis. In studies, very positive results have been obtained with stem cell therapy.

 What is Dementia?

Dementia, popularly known as dementia, is a state of insufficiency in mental functions such as memory and language abilities, abstract thinking, and judgment due to the disease.Dementia is the most common cause of disability in people over the age of 60, and the incidence of this disease is increasing as people’s lifespans increase. While the risk of dementia is 5% at the age of 65, the risk doubles every 5 years and reaches 40-50% over the age of 85.It is a known fact that forgetfulness is the most common complaint in old age and it is mostly considered as a natural result of aging, but there may be many medical reasons for forgetfulness in the elderly. Dementia, which is the most common cause of dementia, is one of the important causes of forgetfulness in the elderly.It is known that there are 200 different types of diseases that cause dementia because they weaken the brain. 

What Are the Symptoms of Dementia?

Initial symptoms of the disease;

• Memory problems, forgetfulness and memory loss

• Difficulties in performing routine behaviors

• Difficulty finding the right words• Sudden changes in mood

• Apathy- Indifference, demoralization and insecurity

• Difficulty doing and completing normal daily tasks

• Confusion, inability to remember people’s faces and names

• Difficulty following stories and events

• Unsuccessful sense of direction, getting lost often

• Repetitive behaviors, asking the same questions or telling the same things over and over again• Non-adaptive to change, forgetting why you did something, and panic• Decline in mental skills• Difficulty finding words and remembering the names of objects

• Difficulty making calculations and dealing with numbers

Causes of Dementia

Cognitive losses such as forgetfulness may occur due to advanced age. This age-related condition occurs as a result of nerve cell damage in the brain caused by advancing age and is not dementia. Thyroid dysfunctions such as hypothyroidism, anemia, vitamin B12 and folic acid deficiencies, and some other medical conditions are also causes of forgetfulness in the elderly.The complaint of forgetfulness in the elderly should be taken seriously. As a result of various evaluations, the cause of forgetfulness should be determined. Because some of the problems and diseases that cause dementia are treatable, the progression of the disease can be slowed down. For example, problems such as metabolism disorders, depression, drug side effects, wrong drug use can be prevented. Therefore, early detection of the problem causing dementia is very important. 

Dementia Treatment

The success of dementia treatment depends on the source and severity of the problem causing the disease. Informing patients and their relatives in detail, providing the support they need, is very important for recovery and quality of life. Even if there is no definitive treatment, some new drugs that have been released in recent years reduce the symptoms of dementia and slow down its progression.Treatment for vascular dementia, which can cause blood clots in the brain, is aimed at preventing more blood clots from forming.Dementia patients and their relatives must be informed about the disease, so that it will be easier for them to take precautions for possible problems in the future. 

Dementia Treatment with Stem Cells

Stem cells have the ability to transform into dying brain cells when they touch them, so they are used in the treatment of dementia. The size of the given cells is small enough to penetrate the brain tissues, and the cure rate increases significantly in early diagnosis.The number of cells to be transplanted is determined by the age and weight of the patient. The treatment is carried out using mesenchymal stem cells (obtained from the patient’s own adipose tissue or bone marrow). Which treatment will be applied is decided according to the patient’s condition. 3 sessions with an interval of 45 days or 3 sessions with an interval of 1 week can be performed. The treatment protocol is completely determined according to the patient’s condition, a different protocol can be applied for each patient. The most clear and lasting effects of the applied treatments were achieved at the initial stage of the disease (in 90% of cases), when neurological and mental symptoms appear. Positive results have also been obtained in patients with organic brain lesions (atrophy of the frontoperiatel lobes).It has also been observed that the quality of life (general condition, sleep, appetite, etc.) of the patients increased as a result of the application of stem cells in cases with significant mental disorders.The treatment of this disease can be done at our Clinic and Turkey Stem Cell Treatment Center in Istanbul, Turkey.

FREQUENTLY ASKED QUESTIONS

Is Dementia a Genetic (Hereditary) Disease?

It is known that genetic factors play a role in dementia. A family history of dementia is seen in 30% of patients. This factor is more effective in patients who start at a young age (under 65 years of age).

Are There Any Precautions That Can Be Taken To Avoid Dementia?

It is known that it is important to do sports to avoid dementia. It is thought that doing sports three times a week reduces the likelihood of dementia by 70%. Not smoking, consuming vitamin B12, taking vitamin D, reducing alcohol consumption and brain exercises are among the measures that can be taken against dementia.

How Is Dementia Diagnosed?

The most important symptom of dementia is the state of forgetfulness noticed in the patient. However, it is not correct to consider all forgetfulness as Dementia. Many people experience forgetfulness in their daily life, but continue to live without Dementia.People who are thought to have dementia should be evaluated with neurological examinations, laboratory tests and neuropsychological tests. EEG, cortical mapping, MRI, and PET scan may also be recommended for people at high risk.

Stem Cell Therapy: An MS

Stem cell therapy for Multiple Sclerosis

Stem cell therapy is a new MS infusion treatment aimed at improving disease state by reducing inflammation and regulating immune cells. Stem cell therapy for MS, specifically the administration of mesenchymal stem cells (MSCs) for Multiple Sclerosis, has demonstrated great potential to help improve symptoms and stabilize condition progression.  The immunomodulatory (ability to regulate the immune system), tissue-protective, and repair-promoting properties of MSCs demonstrated in multiple models make them an attractive therapy for Multiple Sclerosis (MS) and other conditions characterized by inflammation/or tissue injury.  

MS Patients may be able to expect an increase in energy, flexibility, strength, mobility, and control of essential functions.  Data is also beginning the show that mesenchymal stem cells (MSCs) administered intravenously may have the ability to halt disease progression for an extended period. (2) 

Is there a cure for MS?

Currently, there is no known cure for Multiple Sclerosis (MS). While there are treatments that can help manage symptoms and slow the progression of the disease, there is currently no way to stop or reverse the damage caused by MS entirely.

There have been several promising areas of research in recent years, including studies on the use of stem cells and other regenerative therapies, as well as the development of new medications. With advances in research and new treatments being developed, a cure for MS may be discovered soon.‍

Is stem cell therapy a cure for MS?

Mesenchymal stem cell therapy is a promising alternative to traditional multiple sclerosis (MS) treatments. Mesenchymal stem cells (MSCs) are a type of stem cell that can differentiate into a variety of cell types, including nerve cells, and can suppress immune response; these cells have been investigated as a potential option to treat multiple sclerosis.

Current research for a Multiple Sclerosis cure

A study published in the Journal of Neuroimmunology in 2018 showed that an animal model of secondary progressive multiple sclerosis  treatment with mesenchymal stem cells (MSCs) significantly reduced inflammation and improved neurological function. (6)

‍Can stem cells regrow myelin?

Studies have shown that stem cells have the potential to repair myelin sheath. This protective covering surrounds nerve fibers in the central nervous system, which is damaged in MS. In addition, mesenchymal stem cells (MSCs) can modulate the immune response, which is thought to be involved in the development of MS. 

This makes MSCs the newest treatment option for MS as they may help to reduce inflammation and slow or even stop the progression of the disease.

Can stem cells reverse nerve damage?

Another study published in Stem Cell Research & Therapy in 2019 suggests that mesenchymal stem cells (MSCs) can protect nerve cells from damage by reducing inflammation and oxidative stress and promoting remyelination. (7)

It’s important to note that stem cell therapy for MS is still in the early stages of research and development. Much more research is needed before it can be considered a standard treatment for MS. Additionally, clinical trials with MSCs are still ongoing. The therapy’s long-term (5-10 years) efficacy is yet to be determined in third-party peer-reviewed studies.‍

Stem cell treatment for MS

Mesenchymal stem cell (MSC) therapy holds significant potential as a treatment option for Multiple Sclerosis (MS). While more research is needed to understand its long-term efficacy, peer-reviewed studies have shown promising results in reducing inflammation and promoting tissue repair in MS patients.

Stem cell treatment for Multiple Sclerosis has demonstrated healing and repair-promoting properties. Expanded cord tissue-derived umbilical cord cells have potentially made it possible to treat MS more effectively. Studies have been conducted on both secondary progressive ms and relapsing-remitting ms.

Mesenchymal stem cells (MSCs) are a natural treatment that can reduce inflammation within the body. Once administered, stem cells help regulate the immune system and prevent further myelin degradation. This makes mesenchymal stem cells (MSCs) an attractive therapy for MS and other conditions characterized by inflammation and/or tissue injury. CAT Stem has even seen patients report significant improvements in symptoms such as peripheral neuropathy.

Stem cell Multiple Sclerosis (MS) treatment advantages

• A growing amount of evidence supporting the ability of mesenchymal stem cells to help regulate the immune system
• Ability to repair damaged myelin sheath (remyelination) or neurons
• Umbilical cord tissue provides a high number of mesenchymal cells
• Stem cells are extremely anti-inflammatory, allowing for the repair and regeneration of tissue
• IV stem cell therapy is NOT invasive and does not require any downtime
• Reduction of debilitating MS symptoms
• Overall stabilization of the condition or extended periods of remission

‍What is the success rate of stem cell therapy for MS?

The success rate of mesenchymal stem cell (MSC) therapy for multiple sclerosis (MS) is still under investigation. Studies on using MSCs in MS have been limited and have shown primarily positive results. Studies for relapsing forms of MS have reported improvement in the symptoms of MS and reduced inflammation following MSC therapy.

A review of studies on MSC therapy for MS found that the treatment was generally safe, with few severe side effects reported. However, the review’s authors noted that the studies included were small and had methodological limitations. Therefore, more research is needed to confirm the safety and efficacy of MSC therapy for MS.

How long does stem cell therapy last for MS?

The duration of the effects of stem cell therapy for Multiple Sclerosis (MS) is still under investigation.  Studies on the use of stem cell therapy for MS have reported varying results, and there is currently no consensus on how long the effects of the treatment last.

Some studies have reported that the benefits of stem cell therapy for MS can last for several years, while others have found that the effects are more short-lived. The impact duration may depend on the type of stem cell therapy used, the stage of the disease, and the individual patient.

New treatments for MS: Phase II double-blind trial shows impressive results

A recent phase II double-blind trial, randomized and controlled by placebo study of 48 patients conducted in Isreal, found that mesenchymal stem cell therapy improved MS symptoms in roughly 73% of participants. At the same time, disease progression was halted entirely in approximately 60% of participants. (2)

Results

The study revealed positive results in all predefined primary endpoints. No serious, treatment-related adverse effects were observed, and significantly fewer patients in the MSC-IT and MSC-IV groups experienced treatment failure. (2) One of the researchers in this study, Petrou et al state:

“Overall, the robust effects of MSC transplantation on various parameters that reflect neurological dysfunction and especially on multiple sclerosis activity may indicate the involvement of (central and peripheral) immunomodulatory and possibly also neuroprotective mechanisms.‍

Discussion

These benefits seem of particular clinical significance, as they were observed in patients with progressive multiple sclerosis unresponsive to conventional immunotherapies, and for which limited treatment options exist.” This study found that mesenchymal stem cell transplantation did have an immunomodulatory effect that positively impacted the MS patients in the study.  

Stem cells and Multiple Sclerosis

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) with a solid degenerative component, leading to irreversible disability. Mesenchymal stem cells (MSCs) have been shown to prevent inflammation and neurodegeneration in MS.

“Mesenchymal stem cells (MSC) are stromal [precursor] cells residing in many tissues, including the bone marrow (BM), where they support hematopoiesis. Treatment with MSC improves the course of the preclinical model of MS, experimental autoimmune encephalomyelitis (EAE) when administered at early stages. In EAE, MSC has a profound anti-inflammatory and immune-modulating effect [5–9], but they also exhibit neuroprotective features and foster remyelination endogenous neurogenesis with scarce evidence of differentiation in neural cells” – Antonio Uccelli

Mesenchymal stem cells (MSCs) have immune regulatory properties that may have the ability to prevent the immune system from attacking the myelin sheath surrounding nerve fibers. Mesenchymal stem (MSCs) cells may be able to regenerate scar tissue (damaged myelin sheath) of the affected neurons. (also called remyelination)‍

Stem cell replacement to help Multiple Sclerosis (MS) at CAT Stem

The adult stem cells used at CAT Stem are sourced from ethically donated full-term human umbilical cord tissue (Allogeneic Mesenchymal Stem Cells). The tissue is only sourced from the American Association of Tissue Banks (AATB) and cultured and expanded in our cGMP, FDA 351 & 361 compliant, IRB-approved partner lab in the United States. This ensures that all human umbilical cord tissue is screened and tested for infectious disease and that the cells’ expansion process follows US safety standards.

‍MS stem cell treatment cost

The cost of stem cell therapy for MS can range anywhere between $25,000 – $50,000 USD. Learn more about the cost of stem cell treatment for MS at CAT Stem here.

What is Multiple Sclerosis (MS)?

Multiple Sclerosis (MS) is a chronic autoimmune central nervous system disorder. (1) Multiple Sclerosis (MS) is a chronic disease that causes issues with vision, balance, coordination, muscle control, and other essential body functions. Multiple sclerosis, which causes inflammation and brain and spinal cord damage, can disrupt normal nerve signaling, leading to various symptoms.

The effects differ for each person; some have mild symptoms, while others may have severe symptoms that can prevent them from completing daily tasks.  There are two types of MS; primary progressive ms (PPMS) and relapsing-remitting ms (RRMS).‍

Primary Progressive MS

Primary Progressive Multiple Sclerosis is a type of Multiple Sclerosis (MS) characterized by a gradual worsening of symptoms from the onset of the disease, with no relapses or remissions. It is considered a less common form of MS, accounting for 10-15% of all MS cases. Symptoms of PPMS can include difficulty walking, fatigue, muscle weakness, and spasticity. There is no currently FDA-approved treatment specifically for PPMS.

Relapsing-Remitting MS

Relapsing-Remitting Multiple Sclerosis is the most common type of MS, accounting for about 85-90% of all MS cases. People with RRMS experience relapses or exacerbations, where symptoms suddenly worsen or new symptoms appear, followed by periods of remission, where symptoms improve or disappear. Symptoms of RRMS can include fatigue, numbness or tingling in the limbs, muscle weakness, and problems with coordination and balance. There are several FDA-approved treatment options for RRMS, including disease-modifying therapies (DMTs) that can slow the progression of the disease and reduce the frequency and severity of relapses.  Many alternative medicines, such as stem cell therapy and HSCT, may be able to help MS relapses.‍

What causes MS?

MS is induced by an autoimmune issue that causes the patient’s immune system to attack the myelin sheath, a fatty material that surrounds the nerve fibers to protect them. Without this protective outer layer, the nerve cells become vulnerable to damage, resulting in scar tissue. This damage prevents the brain from sending signals throughout the body resulting in a loss of strength, control, and sensation.

As a result, people experience symptoms such as:

• Pain
• Depression
• Fatigue
• Trouble walking
• Blurred vision
• Numbness or tingling
• Drop foot
• Muscle weakness or spasms‍

What age group is typically affected by Multiple Sclerosis (MS)?

Multiple Sclerosis (MS) Symptoms typically start between 20 and 40. People can have relapses (periods of worsening symptoms) and periods of recovery where symptoms feel like they are improving. As the disease progresses, symptoms will worsen for most people. Promising studies have shown the efficacy of stem cell therapy and its ability to improve symptoms and even halt disease progression. (This will be explained further below)‍

What causes Multiple Sclerosis (MS)?

Scientists still do not know precisely what causes Multiple Sclerosis (MS), but several factors seem to make the disease more likely, including; smoking and certain genetic factors. Certain viral infections, such as Epstein-Barr virus or the Human Herpesvirus 6, which both have immunosuppressive properties, may trigger the disease or cause a relapse. Scientists are studying the link between viruses and Multiple Sclerosis (MS) but have not published conclusive data confirming the connection.‍

Is there a cure for Multiple Sclerosis (MS)?

Currently, there is no cure for Multiple Sclerosis (MS). Still, several treatments can be prescribed to manage the symptoms of MS. Unfortunately, these treatments can be pretty expensive and can reach upwards of $100,000 a year for the newest MS drugs.  Studies have shown that Disease modifying therapies (DMTs) can improve the symptoms of Multiple Sclerosis by decreasing the frequency and severity of relapses and slowing the progression of the disease. Studies indicate that starting DMT treatment early after diagnosis can improve outcomes.

HSCT vs stem cell therapy

Mesenchymal stem cell therapy (MSCT) and HSCT are very different procedures. Hematopoietic stem cell transplantation (HSCT) should generally be considered a high-dose immunosuppressive therapy with hematopoietic stem cell support. Rather than an alternative type of stem cell therapy.

Mesenchymal stem cell therapy has shown similar outcomes to HSCT without the need for aggressive cytotoxic drugs (Chemotherapy). It is also important to note that cord tissue-derived mesenchymal stem cell therapy has shown the ability to avoid a negative response from a person’s immune system, allowing the cells to be transplanted in a wide range of people without fear rejection. These transplants vastly increase the body’s natural healing abilities and have potent anti-inflammatory and immunosuppressive responses.  ‍

Which treatment is more effective?

Many peer-reviewed studies have found that mesenchymal stem cell therapy (MSCT) has potent anti-inflammatory and immunosuppressive properties. In many different models, the intravenous administration of mesenchymal stem cells (MSCs) can improve the healing of neural, renal, and lung injuries. (7) Mesenchymal stem cell therapy (MSCT) also can induce large periods of remission and may help improve MS symptoms, including; loss of strength, mobility, flexibility, numbness, and overall mobility.

The two treatment options (HSCT & MSCT) aim to achieve the same outcome: prevent relapses and new MRI lesions, and improve disability.

Mesenchymal stem cell therapy (MSCT) aims to prevent relapses and new MRI lesions and improve disability without invasive cytotoxic immunosuppression therapy (Chemotherapy). MSCT can reduce inflammation and regulate the immune system, which is vital in helping improve MS symptoms and promote disease remission.

According to a recent study published by Regmi and colleagues:

“The immunosuppressive activities of MSCs are initiated by cell-to-cell contact and the release of immunoregulatory molecules. By doing so, MSCs can inhibit the proliferation and function of T cells, natural killer cells, B cells, and dendritic cells, and can also increase the proliferation of regulatory T cells.” (5)

Choose the treatment that is right for you

Results for Hematopoietic Stem Cell Transplants (HSCT) have been mostly positive for autoimmune diseases, such as Multiple Sclerosis, in which the immune system attacks a patient’s body. The treatment “resets” the immune system, hoping to cease the effects of the disorder. 

However, many patients may be turned off by chemotherapy and the inherent risks associated with such aggressive treatment. Some patients may be in too poor a condition to even attempt this form of therapy. Although safety has dramatically improved with experience, HSCT initially had a 1 in 100 death rate for participants.

Mesenchymal stem cell therapy (MSCT) is a much less invasive and radical procedure, having little impact on the patient. Mesenchymal stem cell therapy (MSCT) gives patients an option for effective treatment without the risk of chemotherapy or who may be too poor to undergo Hematopoietic Stem Cell Transplants HSCT. Additionally, the non-invasive nature of Mesenchymal Stem Cell Therapy (MSCT) allows for repeat treatment over time without continuous damage being done to the body.‍

So does the immune system need to be destroyed to help neurological conditions such as MS effectively?

No, it does not. Published studies have found that Mesenchymal stem cell therapy (MSCT) can reduce inflammation and regulate the immune system without invasive immunosuppressive treatments (chemotherapy).  Mesenchymal stem cells also offer intrinsic benefits that hematopoietic stem cells do not, such as the ability to differentiate into a variety of cell types, the release of immunoregulatory molecules, promote the release of exosome and growth factors.

Are stem cells safe?

Umbilical cord tissue-derived mesenchymal stem cells do not have any risk of rejection within the body. They are youthful, immune-privileged, undifferentiated cells. There are no blood products associated with this type of MSC either, removing the need for a donor match, they are universally accepted. These cells seek out inflammation in the body and begin to heal the damaged tissue. 

Mesenchymal cord tissue-derived stem cells have been administered thousands of times at clinics worldwide. There have never been any recorded instances of rejection (graft vs. host disease).‍

Benefits of stem cell therapy for MS

​Other potential advantages of mesenchymal stem cell therapy for people with MS include the injected cells’ ability to move from the bloodstream to areas of injured tissues, allowing for a comfortable IV administration of these cells into the body. The stem cells will then be attracted to those areas of injury or inflammation and begin the differentiation process to begin the healing process. Stem cell transplants for MS are generally less invasive, have shorter recovery times, and have lasting healing effects on the body.‍

Want to learn more about stem cell therapy for MS at CAT Stem?

CAT Stem is a stem cell therapy pioneer, offering stem cell therapies for years, and has become a cornerstone of the medical tourism industry. Located in the tropical paradise of Grand Cayman in the Western Caribbean, we offer patients a nearby alternative to traveling long distances and to less ideal locations. Our protocols are IRB approved, and our cells come from regulated, US-based, FDA-compliant laboratories.

We seek to offer the highest quality products, the latest treatments for various conditions, and a world-class setting and service. We administer over 300 million cord tissue-derived mesenchymal stem cells via IV, our treatments are minimally invasive, and we offer interest-free financing for US residents.

ALZHEIMER TREATMENT WITH STEM CELLS

With stem cell therapy, the progression of Alzheimer’s disease can be slowed down and regressed, and even stopped completely. The success rate of the treatment is proportional to the patient’s age, the duration of the disease and the patient’s condition. If the disease has severely progressed, treatment may need to be repeated more than once.

• The treatment of Alzheimer’s disease with stem cells is recognized as a new method that scientists are working on.
• Stem cells have the ability to turn into brain cells when they touch these cells, and that being the case, they are used in the treatment of Alzheimer’s disease.
• Stem cell therapy is used in autoimmune system diseases because it has the effect of improving, triggering and regulating the body’s autoimmune (defense/immune) system. Since the regulation of the autoimmune system has positive effects in the treatment of Alzheimer’s disease, stem cells are once again important in the treatment of the disease.
• Stem cells are used in the treatment of aged and weakened organs in the body as well. Therefore, they are also effective in treating organs with impaired functions due to aging or Alzheimer’s.
• The size of the administered stem cells is small enough to pass through the brain cells. Therefore, the success rate of the treatment increases significantly in early diagnosis. The treatment protocol is precisely determined according to the patient’s condition and a different protocol is applied for each patient.
• Previous studies reported a very high percentage of positive results with stem cell therapy. This treatment significantly prevented progression to further phases of the disease in 75% of the patients and helped to resolve the existing serious condition.

What is Alzheimer’s?

Alzheimer’s disease is one of the most common types of dementia (diminished mental skills due to disease). Although the cause of the disease has not been fully identified, Alzheimer’s is caused by premature death of brain cells or by shrinkage of these cells, resulting in them losing their activity.

Exactly as in the case of dementia, Alzheimer’s is a disease progressing from disruption of daily activities to failure of the patient to express himself/herself, impairment of his/her relations with the environment, deterioration of his/her calculation judgment skills and perception in further stages, which causes personality changes, a number of psychological symptoms in later stages.

In later stages of the disease, the patient becomes unable to even take care of himself/herself. S/he may become bedbound and fail to fulfill his/her daily needs and become a completely dependent patient.

What are the symptoms of Alzheimer’s disease?

Initial symptoms of the disease;

• As the nerve cells in the brain begin to die, short-term forgetfulness occurs as well. (the patient cannot remember what s/he did and what s/he ate the day before).
• She/he can’t remember words, dates, or directions he/she already knew.
• She/he begins to find it hard to make calculations and practical thinking.
• She/he forgets the places of things (puts them in elsewhere)
• As the disease progresses, he/she cannot complete his/her daily routine and he/she asks the same questions again and again, and begins not to recognize his/her relatives.
• His/her character traits change and s/he may start blaming people.
• The patient whose psychology deteriorates becomes introverted.
• She/he avoids assuming responsibility.
• She/he cannot meet his/her needs such as speaking, walking, going to the toilet, and becomes bed bound.

Causes of Alzheimer’s Disease

Alzheimer’s disease occurs when the brain cells die earlier than programmed, the cause of which is not fully understood. (Every person experience brain cell death with age, but in Alzheimer’s disease, this process occurs very quickly and earlier than expected). Although it is seen very rare (in approximately 5 out of 100 patients), it has genetic forms as well.

Although the exact cause of the disease is not known, a number of conditions causing risk include age, past depression, vascular diseases, and serious head injuries in the past.

Alzheimer’s Treatment

The effects of the Alzheimer’s can be slowed down with the medication currently used for this disease. This increases the use of mental functions of Alzheimer’s patients, delaying them to live in a dependent state. However, since there is no definite treatment of the disease with drugs, it is very important that people with Alzheimer’s disease and their relatives receive support services.

Treatment of Alzheimer’s with Stem Cells

Stem cells have the ability to turn into brain cells when they touch dying brain cells, and that being the case, they are used in the treatment of Alzheimer’s disease. The size of the cells given is small enough for them to penetrate into the brain tissues and therefore, the recovery rate increases significantly in early diagnosis.

The number of cells to be administered is determined according to the age and weight of the patient. Treatment is carried out using mesenchymal stem cells (derived from the patient’s own adipose tissue or bone marrow). The treatment of the patient is decided according to the condition of the patient. It can be done in 3 sessions with 1 week intervals or 3 sessions with 3 days intervals The treatment protocol is precisely determined according to the patient’s condition and a different protocol may be applied for each patient. The most obvious and lasting effects of the treatments were obtained in the initial stage of the disease, in which neurological and mental symptoms have appeared (in 90% of the cases). Positive results were also obtained in patients with organic brain lesions (atrophy of the frontoparietal lobes). If the disease is too advanced and no adipose tissue can be removed from the patient, using “fetal stem cells” may be recommended for treatment.

As a result of application of stem cells in patients with significant mental disorder, the quality of life of the patients significantly increased (general condition, sleep, appetite, etc.) as well.

This disease can be treated at our Clinic and Turkey Stem Cell Treatment Center in İstanbul, Turkey.

FREQUENTLY ASKED QUESTIONS

Is Alzheimer’s a Genetic (Hereditary) disease?

Genetic factors are known to play a role in Alzheimer’s disease. 30% of the patients have dementia in their families. This factor is more effective in patients diagnosed at a younger age (under 65 years old).

Are there any precautions to avoid Alzheimer’s disease?

It is known that doing sports is important to avoid Alzheimer’s. It is believed that doing physical exercise three times a week reduces the chance of dementia by 70%. Not smoking, consuming vitamin B12, taking vitamin D, reducing alcohol consumption and brain exercises are some of the measures that can be taken against Alzheimer’s.

How is Alzheimer’s diagnosed?

The most important symptom of Alzheimer’s disease is the patient’s forgetfulness. However, it is not right to consider all forgetfulness as Alzheimer’s. Many people experience forgetfulness in their daily lives, but continue to live without Alzheimer’s.
Patients considered to have Alzheimer’s disease should be evaluated with neurological examinations, laboratory tests and neuropsychological tests. To people at high risk, EEG, i.e. cortical mapping, MRI and PET scans may also be recommended.

ALS (AMYOTROPHIC LATERAL SCLEROSIS)

Treatment of ALS (Amyotrophic Lateral Sclerosis) with Stem Cells

With stem cell therapy, the progression of ALS disease can be slowed down and regressed, and even stopped completely. The success rate of the treatment is proportional to the patient’s age, the duration of the disease and the patient’s condition. As a result of the improvement in the muscles, the patient’s quality of life increases significantly.

• The treatment of ALS disease with stem cells is recognized as a new method that the scientists have been working on since the 1990s.
• Stem cells have the ability to turn into nerve cells and muscle cells when they touch these cells. Stem cells are therefore used in the treatment of ALS.
• The number of cells to be administered is determined according to the age and weight of the patient. The treatment is performed in 3 sessions with 1 week intervals or  3 sessions with 3 days intervals. The treatment protocol is precisely adjusted according to the patient’s condition and a different protocol is applied for each patient.
• Following stem cell transplantation to ALS patients who have not responded to drug therapies or have not shown adequate response, 67% of the patients showed decreased weakness, increased appetite, improved psychological state and decreased spasticity intensity.

What is ALS?

ALS, medically Amyotrophic Lateral Sclerosis, or Motor Neuron Disease, is a medical term describing myolysis and damage to the spinal cord. It is caused by the loss of motor nerve cells (neurons) in the spinal cord and the area called brain stem of central nervous system. Loss of these cells leads to weakness and wasting away (atrophy) of muscles.

ALS was first described in 1869 by Jean-Martin Charcot, a French neurologist and pioneer in his field. For this reason, the disease was originally named Charcot Disease.

What are the symptoms of ALS?

The initial symptoms of ALS are not the same in each patient. Generally, weakness or thinning in an arm or a leg is the first symptom noticed. For example, holding a pencil, buttoning up, carrying a bag become hard or the patient stumbles while walking.
In some patients, the disease starts with difficulty in speech or swallowing. The patient himself/herself or their relatives may notice lisping or a nasal speech. Twitching, pain and cramps in muscles may accompany these symptoms. Symptoms may include uncontrollable crying and laughing.

Weakness spreads over time from the site of onset to the other limbs (arms, legs, tongue and pharyngeal muscles). The patient’s daily life activity may be restricted due to wasting away, weakness and twitches in muscles of the whole body. S/he may become unable to do anything on his/her own. S/he can’t eat, get dressed or have a bath/shower. S/he may even become unable to get out of bed.

The critical period of the disease is when the respiratory muscles become weak. When respiratory and nutritional deficiencies occur, the patient needs fast and close medical support. 10% of patients may have both ALS and Dementia (decreased mental skills due to disease).

Causes of ALS

The exact cause of ALS is not precisely known. However, genetic factors, exposure to environmental toxins, smoking and various chemicals that damage cells are deemed to increase the risk of ALS.

As is the case with many diseases, regional factors are among the causes of ALS. In three regions in the Western Pacific, Japan’s Kii Peninsula and West Papua New Guinea, the rate of this disease is 140 cases per hundred thousand people.

Treatment of ALS

Since there is no common treatment method, case-based supportive drug therapies and occasional intensive care treatments are being applied. In addition, symptomatic therapies play an important role in improving the quality of life. Another factor is healthy and balanced nutrition, eating frequent but light foods, consuming liquids, and maintaining ideal weight.

Treatment of ALS with Stem Cells

Stem cells have the ability to turn into neurons, i.e. nerve cells when they touch dying nerve cells, and that being the case, they are used in the treatment of ALS disease. At the same time, the stem cells have the ability to turn into the muscle cells they touch. Therefore, they provide treatment for the weakened muscles. The size of the cells given is small enough for them to penetrate into nerve and muscle tissues. Therefore, the recovery rate increases significantly in early diagnosis.

First of all, the number of cells to be administered is determined according to the age and weight of the patient and treatment is carried out using mesenchymal stem cells . The decision is made according to the patient’s condition. The treatment is performed in 3 sessions with 1 week intervals or 3 sessions with 3 days intervals. Upon applying stem cell therapy to ALS patients who have not shown adequate response to the drug treatments, 67% of the patients showed decreased weakness, increased appetite, improved psychological state and decreased spasticity intensity. 34% of patients were reported to have increased mobility and muscle strength of hands and feet, normalized reflexes, decreased fiber zones, better tolerability of daily work, (improvement in swallowing, speech, pronunciation) in about 2 months as from stem cell transplantation.
48% of the patients are advised to repeat the treatment annually in order for them to have continued positive results. 25% of cases required 2 years of regular stem cell transplantation.

This treatment can be administered at our Clinic and Turkey Stem Cell Treatment Center in İstanbul, Turkey

FREQUENTLY ASKED QUESTIONS

Who is most likely to have ALS?

ALS Disease can occur in all parts of the world and in every segment of the society. It’s a bit more common in men. The average age of onset is 55. However, it can be seen at a very young age as well as a very old age. 2-6 in a hundred thousand of the world’s population have ALS.

Is ALS a Genetic (Hereditary) disease?

90% of all ALS patients have coincidental and 10% have familial ALS. Therefore, the disease can be said to be mostly unrelated to heredity. Recently, many mutations estimated to be related to ALS disease have been found. ALS is not a contagious disease. A patient’s relatives and those dealing with their treatment are not infected by this disease.

Why ALS causes loss of power?

In order to perform a movement, our muscles related to that movement should be able to contract voluntarily. Two groups of nerves, called motor nerves, serve for the muscles to contract according to need. When we want to make a movement, the stimulation from the relevant part of our brain is first delivered to the spinal cord by the first group of motor nerves. Other motor nerves waiting there are stimulated. This second group of nerves leave the spinal cord and go to the relevant muscle to make it contract. If the motor nerves are damaged, voluntary muscle contraction is impaired, and the patient loses power partially or completely.

Are there muscles not affected by the disease?

The disease does not affect all the muscles of the body. The patient can control intestines and urine. Sexual functions are not affected. The heart muscle is not damaged. The eye muscles are often the last affected muscles, and sometimes they are not affected at all.

How is ALS diagnosed?

Basically, clinical signs and symptoms are used to make the diagnosis. ALS, which is a motor neuron disease, can be confused with MS (Multiple Sclerosis) or Parkinson’s disease in the early stages. Therefore, the diagnosis can only be made if the patient undergoes some preliminary tests by a neurologist or physician specialist.

STEM CELL THERAPY FOR CHRONİC OBSTRUCTİVE PULMONARY DİSEASE (COPD or Lung Disease)

Stem cells have the unique ability to change into any cell in the body, called differentiation. They can be administered intravenously and find damaged tissues around organs. When used in regards to COPD patients, stem cells can repair damaged lung tissue to combat emphysema or chronic bronchitis. Stem cells have natural anti-inflammatory properties, which can clear airways for those with chronic bronchitis.

Completed studies have shown the ability to quantify the effects of stem cell therapy. According to a report done by the Lung Institute called Autologous Stem Cell Therapy and its Effects on COPD, over 82% of patients that attempted stem cell treatment had noticeable improvements in their quality of life after their therapies. Many of these patients reported increased lung capacity and the ability to walk following transfusion. These reports have positioned stem cells as one of the best viable options for current patients with COPD. (3)

While stem cell treatment has not shown the ability to cure COPD, its ability to repair damaged tissue and relatively invasive nature makes it an attractive alternative to patients. This path becomes even more desirable when considering the current treatment protocols requiring the use of ventilators or even total lung transplants, which are rare and extremely expensive.

What is Chronic Obstructive Pulmonary Disease? (COPD or Lung Disease)

Chronic Obstructive Pulmonary Disease (COPD or Lung Disease) can describe a group of lung conditions (diseases) that may inhibit the body’s ability to remove air from the lungs. COPD can lead to symptoms such as; fatigue and shortness of breath (breathlessness). Chronic Obstructive Pulmonary Disease (COPD or Lung Disease) can be used to describe a person with emphysema, chronic bronchitis, or a combination of the two.

‍The primary cause of Chronic Obstructive Pulmonary Disease (COPD or Lung Disease) is tobacco smoke, either active smoking or secondhand smoke. Inhaling smoke or other airborne irritants or pollutants can increase mucus production in one’s bronchial tubes (bronchi), this can cause inflammation in the form of thickening bronchi walls. Symptoms of increased mucus production in the bronchial tubes include; frequently coughing, resulting in raising mucus (phlegm). COPD can develop over long periods or a short period when pollutants are inhaled in excess.

How Chronic Obstructive Pulmonary Disease (COPD or Lung Disease) is diagnosed

“Chronic obstructive pulmonary disease (COPD) includes both chronic bronchitis and emphysema. Most individuals with COPD have a little bit of both but have a predominance of one or the other. Your doctor will ask questions about your family history with respiratory illnesses, your symptoms, and the medicines you use, and ask questions about your lifestyle. He or she will conduct a physical exam and order some laboratory tests to diagnose and assess the severity of your COPD.

In 2008, 13.1 million US adults (ages 18 and over) were estimated to have Chronic Obstructive Pulmonary Disease (COPD or Lung Disease). However, close to 24 million US adults have evidence of impaired lung function, indicating an under-diagnosis of Chronic Obstructive Pulmonary Disease (COPD or Lung Disease).

In 2008, an estimated 9.8 million Americans reported a physician diagnosis of chronic bronchitis, the inflammation, and eventual scarring of the lining of the bronchial tubes. Chronic bronchitis affects people of all ages, although people age 65 and older have the highest rate at 56.3 per 1,000 population.”

Is COPD curable?

There is no cure for chronic obstructive pulmonary disease (COPD), but treatment can help manage the symptoms and slow the progression of the disease. COPD is a progressive lung disease that includes chronic bronchitis, emphysema, and sometimes asthma symptoms. It is characterized by inflammation and damage to the airways and lung tissue, which leads to difficulty breathing.

‍Current treatments for COPD

Treatment for COPD generally focuses on relieving symptoms, preventing further damage to the lungs, and improving quality of life. Below are some examples of how you can repair lung damage:

1. Medications: Bronchodilators, corticosteroids, and other medications can help open the airways and reduce inflammation, making it easier to breathe.
2. Oxygen therapy: For people with severe COPD, oxygen therapy may be necessary to provide enough oxygen to the body. This may involve using an oxygen tank or portable oxygen concentrator.
3. Pulmonary rehabilitation: This program of exercise and education can help improve physical conditioning and quality of life for people with COPD.
4. Surgery: In some cases, surgery may be necessary to remove damaged lung tissue or to repair a damaged airway.
5. Stem cell therapy: There is some evidence that stem cell therapy for lungs may be effective in improving lung function and reducing inflammation in people with COPD. However, the effectiveness of stem cell therapy for COPD is still being studied, and more research is needed to determine its long-term effectiveness.

It is important for people with COPD to work closely with their healthcare team to develop a treatment plan that meets their needs.

Stem cells for COPD treatment

Current treatment for COPD involves the use of anti-inflammatory drugs combined with other therapies. However, current therapies have limited effectiveness. A recent study conducted by Phuong Le et al. has shown that allogeneic umbilical cord-derived mesenchymal stem cell transplantation is both a safe and effective treatment option for both moderate to severe COPD (Chronic Obtrusive Pulmonary Disease) patients. 

Study Methods

Twenty patients were enrolled in the study, patients were infused with expanded allogeneic umbilical cord tissue derived mesenchymal stem cells (MSCs). All patients were followed for 6 months after the first infusion. The treatment end-point included a comprehensive safety evaluation, pulmonary function testing (PFT), and quality-of-life indicators including questionnaires, the 6-min walk test (6MWT), and systemic inflammation assessments. All patients completed the full infusion and 6-month follow-up.

Results

The study concluded that MSC treatment was safe. There were no infusion-related toxicities, deaths, or severe adverse events occurred that were deemed related to UC-MSC administration. The UC-MSC-transplanted patients showed a significantly reduced Modified Medical Research Council score, COPD assessment test, and number of exacerbations. This study showed that allogeneic non-HLA-matched UC-MSC transplantation is a safe treatment that improved the quality of life of COPD patients. This clinical study was the first to use allogeneic MSCs from umbilical cord tissue to treat COPD.

EXOSOME

What is Exosome?

Exosomes are very small vesicles with a diameter of 30-150 nanometers and about 1/1000 of the size of a cell, with a membrane made of lipid released from all cells, carrying genetic information, growth factors and proteins.

Exosomes provide intercellular communication and carry the molecules, which are important regulators of intracellular information, between nearby and distant cells.

Exosomes have high potential for use in cell regeneration and repair in the field of regenerative medicine.

Exosomes’ Mechanism of Action

    The primary function of exosomes is to improve intercellular communication by releasing the responses to stimuli and signaling molecules.

    Exosomes can change cell behavior by transferring certain genetic information, proteins and receptors between cells. Given these properties, exosomes play a role in cell proliferation and tissue regeneration.

   Exosomes exert an anti-inflammatory effect by suppressing inflammatory proteins and stimulating anti-inflammatory proteins.

   Exosomes exhibit regenerative activity by stimulating the proliferation of fibroblasts, endothelial cells, keratinocytes and specific endogenous progenitor cells (ancestral cells) and their migration to the damaged area.

   Various studies have demonstrated that exosomes derived from mesenchymal stem cells reduce apoptosis (programmed cell death) that occurs in tissues damaged as a result of disease or injury.

   Exosomes provide tissue regeneration by enhancing the regular cross-collagen bond structure, and heal the damaged tissue as closely as possible to

regular tissue by reducing scarring.

Exosomes’ Advantages

   Mesenchymal stem cell-derived exosomes do not cause tissue rejection since they do not carry human leukocyte antigens (HLA). Thus, they are suitable for allogeneic use.

   Exosomes are not cells and are smaller in size than cells. The most important difference of exosomes from adult stem cells is that they are obtained from newborns and have a higher potential in clinical and aesthetic use given the much higher amount of growth factor they contain.

  As structures that contain protein, exosomes can last long periods without a

deterioration in their main structure in appropriate conditions. There is no requirement to apply exosomes within a limited time by the doctor after dissolution in the laboratory, which is the case for cellular products.

  Exosomes are superior to autologous products in that they come in a directly injectable bottle and do not require surgery, thereby significantly reducing complications.

  Another reason why exosome thrapy is superior to autologous stem cell therapy is that mesenchymal stem cell-derived exosomes are obtained from newborn umbilical cord tissue, a pure and toxin-free tissue that has not  been exposed to any external factors, compared to autologous stem cells that have the same age and quality as the patient.

  Exosomes can be freeze dried, packaged and transported.

  Exosomes can be used in systemic treatment without the risk of clumping.

  Exosomes can be administered intravenously, intramuscularly, locally or by injection into the skin.

What is ExoStem?

ExoStem are protein vesicles obtained by purification through special processes from the culture medium of mesenchymal stem cells (MSCs) obtained from newborn umbilical connective tissue, which have the capacity to regulate cellular and biochemical events that play a role in skin rejuvenation/cell regeneration, and contain many growth factors.

Mesenchymal stem cell-derived exosomes are preferably used in regenerative medicine. These cells are excellent regenerative cells due to their multipotent nature. Therefore, exosomes derived from Mesenchymal Stem Cells are superior to other exosome products.

The physiological effects of the exosomal growth factors in ExoStem can be used to stimulate healing, replenish collagen in aging and damaged skin, and reduce inflammation.

ExoStem has the potential to accelerate healing, improve skin texture, reduce scarring, stimulate hair growth and shorten recovery time after cosmetic procedures.

How is ExoStem Obtained?

Cells obtained from newborn umbilical cord tissue are grown in special culture vessels with cell-specific media. Residues of dead cells are removed from the culture medium of the proliferated cells. After the completion of preliminary steps, exosomes are isolated by spinning the samples at high speed using ultracentrifuge.

The exosomes obtained are passed through quality control tests, placed into vials and stored as such under appropriate conditions.

GROWTH FACTORS FOUND IN THE EXOSTEM AND THEIR EFFECTS

ExoStem is a cell-free product isolated from MSCs derived from umbilical cord tissue. ExoStem product goes through many stages before it is delivered to the user. First, umbilical cord tissues processed in the Clinicandturkey laboratories are received from donors provided that the donors meet the required criteria. To this end, the compliance of the serological test (HIV, Anti-Hbc, HBsAg, HCV, Syphilis, CMV IgG) results of the donor is checked.

ExoStem is prepared under cGMP (current good manufacturing practice) conditions by sterile filtration and resuspension in 0.9% isotonic sodium chloride solution. The product is made ready in sterile vials.

The size and concentration analysis of the particles that make up the ExoStem product content is performed with the ‘Nanoparticle Tracking

Quality Control tests such as sterility, endotoxin, mycoplasma and flow cytometry are performed for each ExoStem product prepared in the Clinicandturkey laboratories, and the product is delivered to the user with the final product certificate containing the test results.

Clinical Applications of Clinicandturkey Exosomes

MSC-Derived Exosomes’ Effects on the Skin

•    Stimulating proliferation and migration of fibroblast cells,   Increasing angiogenesis,
•    Enhancing collagen extracellular matrix and its storage,   Regulating inflammation and immune response,
•    Regulating tissue remodeling-reconstruction.

MSC-Derived Exosomes’ Skin Rejuvenation Effect

• Thanks to their regenerative ability, stem cell-derived exosomes can be used to restore the body’s aging tissues.
• The signs of aging occur due to the inability of the skin to regenerate itself. Exosomes can help maintain the elasticity and strength of the skin.

MSC-Derived Exosomes’ Effect on Hair Loss

•    Increasing the number of hair follicles in the growth phase,
•    Regenerating the dermal papilla cells that make up the hair follicles,
•    With the application of exosome in the early stages of hair loss, the growth factors found in exosome can induce hair regrowth and regrowth in both men and women.
•    Visible changes begin within 1 or 2 months following the first administration of exosome therapy, but the most significant changes are observed between the 6th and 12th months.
•    Exosomes prolong the hair growth hair cycle by converting hair follicles in the resting phase (telogen phase) into the growth phase (anagen phase).

Other Uses of MSC-Derived Exosomes in Dermatology

•   Treatment of spots
•   Acne Scar Treatments
•   Atopic dermatitis/eczema   Wound recovery
•   Treatment of burns

Shelf Life of ExoStem:

• 24 months at -80 °C.
• 6 months at -20 °C-40 °C.
• 1 week at +4 °C.

Special warnings for storage of ExoStem product:

• It is recommended not to re-freeze the frozen product after it has been thawed. Frozen product should be used immediately once it has been thawed.
• Slow thawing should be applied. Frozen product should be kept at room temperature or at +4 °C to thaw.
• Each vial should be used to administer exosomes to only one patient.

The nature and content of the ExoStem product packaging:

The 5 ml sterile vial of the product contains 5×109 (5 billion) particles in 5 ml 0.9% isotonic sodium chloride solution.